Cargando…
Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fu...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068946/ https://www.ncbi.nlm.nih.gov/pubmed/33921294 http://dx.doi.org/10.3390/jof7040290 |
_version_ | 1783683121881808896 |
---|---|
author | Ingrosso, Gianluca Saldi, Simonetta Marani, Simona Wong, Alicia Y. W. Bertelli, Matteo Aristei, Cynthia Zelante, Teresa |
author_facet | Ingrosso, Gianluca Saldi, Simonetta Marani, Simona Wong, Alicia Y. W. Bertelli, Matteo Aristei, Cynthia Zelante, Teresa |
author_sort | Ingrosso, Gianluca |
collection | PubMed |
description | Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as Candida albicans, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy. |
format | Online Article Text |
id | pubmed-8068946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80689462021-04-26 Breakdown of Symbiosis in Radiation-Induced Oral Mucositis Ingrosso, Gianluca Saldi, Simonetta Marani, Simona Wong, Alicia Y. W. Bertelli, Matteo Aristei, Cynthia Zelante, Teresa J Fungi (Basel) Review Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment of patients to deter the development of opportunistic oral fungal infections. Although many clinical protocols already advise the use of probiotics to counteract inflammation and fungal colonization, preclinical studies are needed to better delineate the mechanisms by which a host may acquire benefits via co-evolution with oral microbiota, probiotics, and fungal commensals, such as Candida albicans, especially during acute inflammation. Here, we review the current understanding of radiation therapy-dependent oral mucositis in terms of pathology, prevention, treatment, and related opportunistic infections, with a final focus on the oral microbiome and how it may be important for future therapy. MDPI 2021-04-12 /pmc/articles/PMC8068946/ /pubmed/33921294 http://dx.doi.org/10.3390/jof7040290 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ingrosso, Gianluca Saldi, Simonetta Marani, Simona Wong, Alicia Y. W. Bertelli, Matteo Aristei, Cynthia Zelante, Teresa Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
title | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
title_full | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
title_fullStr | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
title_full_unstemmed | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
title_short | Breakdown of Symbiosis in Radiation-Induced Oral Mucositis |
title_sort | breakdown of symbiosis in radiation-induced oral mucositis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068946/ https://www.ncbi.nlm.nih.gov/pubmed/33921294 http://dx.doi.org/10.3390/jof7040290 |
work_keys_str_mv | AT ingrossogianluca breakdownofsymbiosisinradiationinducedoralmucositis AT saldisimonetta breakdownofsymbiosisinradiationinducedoralmucositis AT maranisimona breakdownofsymbiosisinradiationinducedoralmucositis AT wongaliciayw breakdownofsymbiosisinradiationinducedoralmucositis AT bertellimatteo breakdownofsymbiosisinradiationinducedoralmucositis AT aristeicynthia breakdownofsymbiosisinradiationinducedoralmucositis AT zelanteteresa breakdownofsymbiosisinradiationinducedoralmucositis |