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Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars

Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and...

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Autores principales: Guerrero-Gironés, Julia, Alcaina-Lorente, Antonia, Ortiz-Ruiz, Clara, Ortiz-Ruiz, Eduardo, Pecci-Lloret, María P., Ortiz-Ruiz, Antonio José, Rodríguez-Lozano, Francisco Javier, Pecci-Lloret, Miguel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068992/
https://www.ncbi.nlm.nih.gov/pubmed/33918101
http://dx.doi.org/10.3390/ijerph18083936
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author Guerrero-Gironés, Julia
Alcaina-Lorente, Antonia
Ortiz-Ruiz, Clara
Ortiz-Ruiz, Eduardo
Pecci-Lloret, María P.
Ortiz-Ruiz, Antonio José
Rodríguez-Lozano, Francisco Javier
Pecci-Lloret, Miguel R.
author_facet Guerrero-Gironés, Julia
Alcaina-Lorente, Antonia
Ortiz-Ruiz, Clara
Ortiz-Ruiz, Eduardo
Pecci-Lloret, María P.
Ortiz-Ruiz, Antonio José
Rodríguez-Lozano, Francisco Javier
Pecci-Lloret, Miguel R.
author_sort Guerrero-Gironés, Julia
collection PubMed
description Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges.
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spelling pubmed-80689922021-04-26 Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars Guerrero-Gironés, Julia Alcaina-Lorente, Antonia Ortiz-Ruiz, Clara Ortiz-Ruiz, Eduardo Pecci-Lloret, María P. Ortiz-Ruiz, Antonio José Rodríguez-Lozano, Francisco Javier Pecci-Lloret, Miguel R. Int J Environ Res Public Health Article Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges. MDPI 2021-04-08 /pmc/articles/PMC8068992/ /pubmed/33918101 http://dx.doi.org/10.3390/ijerph18083936 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guerrero-Gironés, Julia
Alcaina-Lorente, Antonia
Ortiz-Ruiz, Clara
Ortiz-Ruiz, Eduardo
Pecci-Lloret, María P.
Ortiz-Ruiz, Antonio José
Rodríguez-Lozano, Francisco Javier
Pecci-Lloret, Miguel R.
Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
title Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
title_full Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
title_fullStr Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
title_full_unstemmed Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
title_short Biocompatibility of a HA/β-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars
title_sort biocompatibility of a ha/β-tcp/c scaffold as a pulp-capping agent for vital pulp treatment: an in vivo study in rat molars
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068992/
https://www.ncbi.nlm.nih.gov/pubmed/33918101
http://dx.doi.org/10.3390/ijerph18083936
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