Cargando…

Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling

Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of Physalis peruviana L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study the matrix effects...

Descripción completa

Detalles Bibliográficos
Autores principales: Domínguez Moré, Gina Paola, Cardona, María Isabel, Sepúlveda, Paula Michelle, Echeverry, Sandra Milena, Oliveira Simões, Cláudia Maria, Aragón, Diana Marcela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069016/
https://www.ncbi.nlm.nih.gov/pubmed/33921404
http://dx.doi.org/10.3390/pharmaceutics13040535
_version_ 1783683138360180736
author Domínguez Moré, Gina Paola
Cardona, María Isabel
Sepúlveda, Paula Michelle
Echeverry, Sandra Milena
Oliveira Simões, Cláudia Maria
Aragón, Diana Marcela
author_facet Domínguez Moré, Gina Paola
Cardona, María Isabel
Sepúlveda, Paula Michelle
Echeverry, Sandra Milena
Oliveira Simões, Cláudia Maria
Aragón, Diana Marcela
author_sort Domínguez Moré, Gina Paola
collection PubMed
description Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of Physalis peruviana L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study the matrix effects of the extract from P. peruviana calyces on the pharmacokinetics of rutin and its metabolites in Wistar rats, using non-compartmental and population pharmacokinetic analyses. A pharmacokinetic study was performed after intravenous and oral administration of different doses of pure rutin and the extract. In the non-compartmental analysis, it was found that rutin from the extract exhibited higher distribution and clearance, as well as an 11-fold increase in the bioavailability of its active metabolites. A population pharmacokinetic model was also carried out with two compartments, double absorption and linear elimination, in which the extract and the doses were the covariates involved. This model correctly described the differences observed between rutin as a pure compound and rutin from the extract, including the dose dependency.
format Online
Article
Text
id pubmed-8069016
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80690162021-04-26 Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling Domínguez Moré, Gina Paola Cardona, María Isabel Sepúlveda, Paula Michelle Echeverry, Sandra Milena Oliveira Simões, Cláudia Maria Aragón, Diana Marcela Pharmaceutics Article Rutin is the rutinose conjugate of quercetin. It presents several biological activities and is the major flavonoid in the hydroalcoholic extract of the calyces of Physalis peruviana L. It also shows hypoglycemic activity after oral administration. The aim of this work was to study the matrix effects of the extract from P. peruviana calyces on the pharmacokinetics of rutin and its metabolites in Wistar rats, using non-compartmental and population pharmacokinetic analyses. A pharmacokinetic study was performed after intravenous and oral administration of different doses of pure rutin and the extract. In the non-compartmental analysis, it was found that rutin from the extract exhibited higher distribution and clearance, as well as an 11-fold increase in the bioavailability of its active metabolites. A population pharmacokinetic model was also carried out with two compartments, double absorption and linear elimination, in which the extract and the doses were the covariates involved. This model correctly described the differences observed between rutin as a pure compound and rutin from the extract, including the dose dependency. MDPI 2021-04-12 /pmc/articles/PMC8069016/ /pubmed/33921404 http://dx.doi.org/10.3390/pharmaceutics13040535 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Domínguez Moré, Gina Paola
Cardona, María Isabel
Sepúlveda, Paula Michelle
Echeverry, Sandra Milena
Oliveira Simões, Cláudia Maria
Aragón, Diana Marcela
Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
title Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
title_full Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
title_fullStr Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
title_full_unstemmed Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
title_short Matrix Effects of the Hydroethanolic Extract of Calyces of Physalis peruviana L. on Rutin Pharmacokinetics in Wistar Rats Using Population Modeling
title_sort matrix effects of the hydroethanolic extract of calyces of physalis peruviana l. on rutin pharmacokinetics in wistar rats using population modeling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069016/
https://www.ncbi.nlm.nih.gov/pubmed/33921404
http://dx.doi.org/10.3390/pharmaceutics13040535
work_keys_str_mv AT dominguezmoreginapaola matrixeffectsofthehydroethanolicextractofcalycesofphysalisperuvianalonrutinpharmacokineticsinwistarratsusingpopulationmodeling
AT cardonamariaisabel matrixeffectsofthehydroethanolicextractofcalycesofphysalisperuvianalonrutinpharmacokineticsinwistarratsusingpopulationmodeling
AT sepulvedapaulamichelle matrixeffectsofthehydroethanolicextractofcalycesofphysalisperuvianalonrutinpharmacokineticsinwistarratsusingpopulationmodeling
AT echeverrysandramilena matrixeffectsofthehydroethanolicextractofcalycesofphysalisperuvianalonrutinpharmacokineticsinwistarratsusingpopulationmodeling
AT oliveirasimoesclaudiamaria matrixeffectsofthehydroethanolicextractofcalycesofphysalisperuvianalonrutinpharmacokineticsinwistarratsusingpopulationmodeling
AT aragondianamarcela matrixeffectsofthehydroethanolicextractofcalycesofphysalisperuvianalonrutinpharmacokineticsinwistarratsusingpopulationmodeling