Cargando…
The Role of the Proteasome in Platelet Function
Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner by performing limited de...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069084/ https://www.ncbi.nlm.nih.gov/pubmed/33924425 http://dx.doi.org/10.3390/ijms22083999 |
_version_ | 1783683154347819008 |
---|---|
author | El-Kadiry, Abed El-Hakim Merhi, Yahye |
author_facet | El-Kadiry, Abed El-Hakim Merhi, Yahye |
author_sort | El-Kadiry, Abed El-Hakim |
collection | PubMed |
description | Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner by performing limited de novo protein synthesis. Furthermore, despite their limited protein synthesis, platelets are equipped with multiple protein degradation mechanisms, such as the proteasome. In nucleated cells, the functions of the proteasome are well established and primarily include proteostasis among a myriad of other signaling processes. However, the role of proteasome-mediated protein degradation in platelets remains elusive. In this review article, we recapitulate the developing literature on the functions of the proteasome in platelets, discussing its emerging regulatory role in platelet viability and function and highlighting how its functional coupling with the transcription factor NF-κB constitutes a novel potential therapeutic target in atherothrombotic diseases. |
format | Online Article Text |
id | pubmed-8069084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80690842021-04-26 The Role of the Proteasome in Platelet Function El-Kadiry, Abed El-Hakim Merhi, Yahye Int J Mol Sci Review Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner by performing limited de novo protein synthesis. Furthermore, despite their limited protein synthesis, platelets are equipped with multiple protein degradation mechanisms, such as the proteasome. In nucleated cells, the functions of the proteasome are well established and primarily include proteostasis among a myriad of other signaling processes. However, the role of proteasome-mediated protein degradation in platelets remains elusive. In this review article, we recapitulate the developing literature on the functions of the proteasome in platelets, discussing its emerging regulatory role in platelet viability and function and highlighting how its functional coupling with the transcription factor NF-κB constitutes a novel potential therapeutic target in atherothrombotic diseases. MDPI 2021-04-13 /pmc/articles/PMC8069084/ /pubmed/33924425 http://dx.doi.org/10.3390/ijms22083999 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review El-Kadiry, Abed El-Hakim Merhi, Yahye The Role of the Proteasome in Platelet Function |
title | The Role of the Proteasome in Platelet Function |
title_full | The Role of the Proteasome in Platelet Function |
title_fullStr | The Role of the Proteasome in Platelet Function |
title_full_unstemmed | The Role of the Proteasome in Platelet Function |
title_short | The Role of the Proteasome in Platelet Function |
title_sort | role of the proteasome in platelet function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069084/ https://www.ncbi.nlm.nih.gov/pubmed/33924425 http://dx.doi.org/10.3390/ijms22083999 |
work_keys_str_mv | AT elkadiryabedelhakim theroleoftheproteasomeinplateletfunction AT merhiyahye theroleoftheproteasomeinplateletfunction AT elkadiryabedelhakim roleoftheproteasomeinplateletfunction AT merhiyahye roleoftheproteasomeinplateletfunction |