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The Role of the Proteasome in Platelet Function

Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner by performing limited de...

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Detalles Bibliográficos
Autores principales: El-Kadiry, Abed El-Hakim, Merhi, Yahye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069084/
https://www.ncbi.nlm.nih.gov/pubmed/33924425
http://dx.doi.org/10.3390/ijms22083999
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author El-Kadiry, Abed El-Hakim
Merhi, Yahye
author_facet El-Kadiry, Abed El-Hakim
Merhi, Yahye
author_sort El-Kadiry, Abed El-Hakim
collection PubMed
description Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner by performing limited de novo protein synthesis. Furthermore, despite their limited protein synthesis, platelets are equipped with multiple protein degradation mechanisms, such as the proteasome. In nucleated cells, the functions of the proteasome are well established and primarily include proteostasis among a myriad of other signaling processes. However, the role of proteasome-mediated protein degradation in platelets remains elusive. In this review article, we recapitulate the developing literature on the functions of the proteasome in platelets, discussing its emerging regulatory role in platelet viability and function and highlighting how its functional coupling with the transcription factor NF-κB constitutes a novel potential therapeutic target in atherothrombotic diseases.
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spelling pubmed-80690842021-04-26 The Role of the Proteasome in Platelet Function El-Kadiry, Abed El-Hakim Merhi, Yahye Int J Mol Sci Review Platelets are megakaryocyte-derived acellular fragments prepped to maintain primary hemostasis and thrombosis by preserving vascular integrity. Although they lack nuclei, platelets harbor functional genomic mediators that bolster platelet activity in a signal-specific manner by performing limited de novo protein synthesis. Furthermore, despite their limited protein synthesis, platelets are equipped with multiple protein degradation mechanisms, such as the proteasome. In nucleated cells, the functions of the proteasome are well established and primarily include proteostasis among a myriad of other signaling processes. However, the role of proteasome-mediated protein degradation in platelets remains elusive. In this review article, we recapitulate the developing literature on the functions of the proteasome in platelets, discussing its emerging regulatory role in platelet viability and function and highlighting how its functional coupling with the transcription factor NF-κB constitutes a novel potential therapeutic target in atherothrombotic diseases. MDPI 2021-04-13 /pmc/articles/PMC8069084/ /pubmed/33924425 http://dx.doi.org/10.3390/ijms22083999 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
El-Kadiry, Abed El-Hakim
Merhi, Yahye
The Role of the Proteasome in Platelet Function
title The Role of the Proteasome in Platelet Function
title_full The Role of the Proteasome in Platelet Function
title_fullStr The Role of the Proteasome in Platelet Function
title_full_unstemmed The Role of the Proteasome in Platelet Function
title_short The Role of the Proteasome in Platelet Function
title_sort role of the proteasome in platelet function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069084/
https://www.ncbi.nlm.nih.gov/pubmed/33924425
http://dx.doi.org/10.3390/ijms22083999
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