Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation

Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including reg...

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Detalles Bibliográficos
Autores principales: Ellias, Samia D., Larson, Ellen L., Taner, Timucin, Nyberg, Scott L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069094/
https://www.ncbi.nlm.nih.gov/pubmed/33924646
http://dx.doi.org/10.3390/ijms22084016
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author Ellias, Samia D.
Larson, Ellen L.
Taner, Timucin
Nyberg, Scott L.
author_facet Ellias, Samia D.
Larson, Ellen L.
Taner, Timucin
Nyberg, Scott L.
author_sort Ellias, Samia D.
collection PubMed
description Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.
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spelling pubmed-80690942021-04-26 Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation Ellias, Samia D. Larson, Ellen L. Taner, Timucin Nyberg, Scott L. Int J Mol Sci Review Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients. MDPI 2021-04-13 /pmc/articles/PMC8069094/ /pubmed/33924646 http://dx.doi.org/10.3390/ijms22084016 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ellias, Samia D.
Larson, Ellen L.
Taner, Timucin
Nyberg, Scott L.
Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
title Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
title_full Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
title_fullStr Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
title_full_unstemmed Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
title_short Cell-Mediated Therapies to Facilitate Operational Tolerance in Liver Transplantation
title_sort cell-mediated therapies to facilitate operational tolerance in liver transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069094/
https://www.ncbi.nlm.nih.gov/pubmed/33924646
http://dx.doi.org/10.3390/ijms22084016
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AT nybergscottl cellmediatedtherapiestofacilitateoperationaltoleranceinlivertransplantation

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