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Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis

There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectivenes...

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Autores principales: Martin-Perez, Antonio Jose, Fernández-González, María, Postigo-Martin, Paula, Sampedro Pilegaard, Marc, Fernández-Lao, Carolina, Castro-Martín, Eduardo, Martín-Martín, Lydia, Lozano-Lozano, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069127/
https://www.ncbi.nlm.nih.gov/pubmed/33920146
http://dx.doi.org/10.3390/ijerph18083991
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author Martin-Perez, Antonio Jose
Fernández-González, María
Postigo-Martin, Paula
Sampedro Pilegaard, Marc
Fernández-Lao, Carolina
Castro-Martín, Eduardo
Martín-Martín, Lydia
Lozano-Lozano, Mario
author_facet Martin-Perez, Antonio Jose
Fernández-González, María
Postigo-Martin, Paula
Sampedro Pilegaard, Marc
Fernández-Lao, Carolina
Castro-Martín, Eduardo
Martín-Martín, Lydia
Lozano-Lozano, Mario
author_sort Martin-Perez, Antonio Jose
collection PubMed
description There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.
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spelling pubmed-80691272021-04-26 Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis Martin-Perez, Antonio Jose Fernández-González, María Postigo-Martin, Paula Sampedro Pilegaard, Marc Fernández-Lao, Carolina Castro-Martín, Eduardo Martín-Martín, Lydia Lozano-Lozano, Mario Int J Environ Res Public Health Study Protocol There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis. MDPI 2021-04-10 /pmc/articles/PMC8069127/ /pubmed/33920146 http://dx.doi.org/10.3390/ijerph18083991 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Study Protocol
Martin-Perez, Antonio Jose
Fernández-González, María
Postigo-Martin, Paula
Sampedro Pilegaard, Marc
Fernández-Lao, Carolina
Castro-Martín, Eduardo
Martín-Martín, Lydia
Lozano-Lozano, Mario
Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
title Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
title_full Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
title_fullStr Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
title_full_unstemmed Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
title_short Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis
title_sort effectiveness of antalgic therapies in patients with vertebral bone metastasis: a protocol for a systematic review and meta-analysis
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069127/
https://www.ncbi.nlm.nih.gov/pubmed/33920146
http://dx.doi.org/10.3390/ijerph18083991
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