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Phage Therapy in Veterinary Medicine

To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological char...

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Autores principales: Loponte, Rosa, Pagnini, Ugo, Iovane, Giuseppe, Pisanelli, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069180/
https://www.ncbi.nlm.nih.gov/pubmed/33920369
http://dx.doi.org/10.3390/antibiotics10040421
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author Loponte, Rosa
Pagnini, Ugo
Iovane, Giuseppe
Pisanelli, Giuseppe
author_facet Loponte, Rosa
Pagnini, Ugo
Iovane, Giuseppe
Pisanelli, Giuseppe
author_sort Loponte, Rosa
collection PubMed
description To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects influencing the success of phage therapy. However, despite their efficacy and safety, there is still no specific legislation that regulates their use. In the second part of this review, we describe the comprehensive research done in the past and recent years to address the use of phage therapy for the treatment and prevention of bacterial disease affecting domestic animals as an alternative to antibiotic treatments. While in farm animals, phage therapy efficacy perspectives have been widely studied in vitro and in vivo, especially for zoonoses and diseases linked to economic losses (such as mastitis), in pets, studies are still few and rather recent.
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spelling pubmed-80691802021-04-26 Phage Therapy in Veterinary Medicine Loponte, Rosa Pagnini, Ugo Iovane, Giuseppe Pisanelli, Giuseppe Antibiotics (Basel) Review To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects influencing the success of phage therapy. However, despite their efficacy and safety, there is still no specific legislation that regulates their use. In the second part of this review, we describe the comprehensive research done in the past and recent years to address the use of phage therapy for the treatment and prevention of bacterial disease affecting domestic animals as an alternative to antibiotic treatments. While in farm animals, phage therapy efficacy perspectives have been widely studied in vitro and in vivo, especially for zoonoses and diseases linked to economic losses (such as mastitis), in pets, studies are still few and rather recent. MDPI 2021-04-11 /pmc/articles/PMC8069180/ /pubmed/33920369 http://dx.doi.org/10.3390/antibiotics10040421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Loponte, Rosa
Pagnini, Ugo
Iovane, Giuseppe
Pisanelli, Giuseppe
Phage Therapy in Veterinary Medicine
title Phage Therapy in Veterinary Medicine
title_full Phage Therapy in Veterinary Medicine
title_fullStr Phage Therapy in Veterinary Medicine
title_full_unstemmed Phage Therapy in Veterinary Medicine
title_short Phage Therapy in Veterinary Medicine
title_sort phage therapy in veterinary medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069180/
https://www.ncbi.nlm.nih.gov/pubmed/33920369
http://dx.doi.org/10.3390/antibiotics10040421
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