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Phage Therapy in Veterinary Medicine
To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological char...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069180/ https://www.ncbi.nlm.nih.gov/pubmed/33920369 http://dx.doi.org/10.3390/antibiotics10040421 |
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author | Loponte, Rosa Pagnini, Ugo Iovane, Giuseppe Pisanelli, Giuseppe |
author_facet | Loponte, Rosa Pagnini, Ugo Iovane, Giuseppe Pisanelli, Giuseppe |
author_sort | Loponte, Rosa |
collection | PubMed |
description | To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects influencing the success of phage therapy. However, despite their efficacy and safety, there is still no specific legislation that regulates their use. In the second part of this review, we describe the comprehensive research done in the past and recent years to address the use of phage therapy for the treatment and prevention of bacterial disease affecting domestic animals as an alternative to antibiotic treatments. While in farm animals, phage therapy efficacy perspectives have been widely studied in vitro and in vivo, especially for zoonoses and diseases linked to economic losses (such as mastitis), in pets, studies are still few and rather recent. |
format | Online Article Text |
id | pubmed-8069180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80691802021-04-26 Phage Therapy in Veterinary Medicine Loponte, Rosa Pagnini, Ugo Iovane, Giuseppe Pisanelli, Giuseppe Antibiotics (Basel) Review To overcome the obstacle of antimicrobial resistance, researchers are investigating the use of phage therapy as an alternative and/or supplementation to antibiotics to treat and prevent infections both in humans and in animals. In the first part of this review, we describe the unique biological characteristics of bacteriophages and the crucial aspects influencing the success of phage therapy. However, despite their efficacy and safety, there is still no specific legislation that regulates their use. In the second part of this review, we describe the comprehensive research done in the past and recent years to address the use of phage therapy for the treatment and prevention of bacterial disease affecting domestic animals as an alternative to antibiotic treatments. While in farm animals, phage therapy efficacy perspectives have been widely studied in vitro and in vivo, especially for zoonoses and diseases linked to economic losses (such as mastitis), in pets, studies are still few and rather recent. MDPI 2021-04-11 /pmc/articles/PMC8069180/ /pubmed/33920369 http://dx.doi.org/10.3390/antibiotics10040421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Loponte, Rosa Pagnini, Ugo Iovane, Giuseppe Pisanelli, Giuseppe Phage Therapy in Veterinary Medicine |
title | Phage Therapy in Veterinary Medicine |
title_full | Phage Therapy in Veterinary Medicine |
title_fullStr | Phage Therapy in Veterinary Medicine |
title_full_unstemmed | Phage Therapy in Veterinary Medicine |
title_short | Phage Therapy in Veterinary Medicine |
title_sort | phage therapy in veterinary medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069180/ https://www.ncbi.nlm.nih.gov/pubmed/33920369 http://dx.doi.org/10.3390/antibiotics10040421 |
work_keys_str_mv | AT loponterosa phagetherapyinveterinarymedicine AT pagniniugo phagetherapyinveterinarymedicine AT iovanegiuseppe phagetherapyinveterinarymedicine AT pisanelligiuseppe phagetherapyinveterinarymedicine |