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Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose v...

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Autores principales: Mieszkowski, Jan, Borkowska, Andżelika, Stankiewicz, Błażej, Kochanowicz, Andrzej, Niespodziński, Bartłomiej, Surmiak, Marcin, Waldziński, Tomasz, Rola, Rafał, Petr, Miroslav, Antosiewicz, Jędrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069287/
https://www.ncbi.nlm.nih.gov/pubmed/33924645
http://dx.doi.org/10.3390/nu13041280
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author Mieszkowski, Jan
Borkowska, Andżelika
Stankiewicz, Błażej
Kochanowicz, Andrzej
Niespodziński, Bartłomiej
Surmiak, Marcin
Waldziński, Tomasz
Rola, Rafał
Petr, Miroslav
Antosiewicz, Jędrzej
author_facet Mieszkowski, Jan
Borkowska, Andżelika
Stankiewicz, Błażej
Kochanowicz, Andrzej
Niespodziński, Bartłomiej
Surmiak, Marcin
Waldziński, Tomasz
Rola, Rafał
Petr, Miroslav
Antosiewicz, Jędrzej
author_sort Mieszkowski, Jan
collection PubMed
description Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.
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spelling pubmed-80692872021-04-26 Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial Mieszkowski, Jan Borkowska, Andżelika Stankiewicz, Błażej Kochanowicz, Andrzej Niespodziński, Bartłomiej Surmiak, Marcin Waldziński, Tomasz Rola, Rafał Petr, Miroslav Antosiewicz, Jędrzej Nutrients Article Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation. MDPI 2021-04-13 /pmc/articles/PMC8069287/ /pubmed/33924645 http://dx.doi.org/10.3390/nu13041280 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mieszkowski, Jan
Borkowska, Andżelika
Stankiewicz, Błażej
Kochanowicz, Andrzej
Niespodziński, Bartłomiej
Surmiak, Marcin
Waldziński, Tomasz
Rola, Rafał
Petr, Miroslav
Antosiewicz, Jędrzej
Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
title Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
title_full Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
title_fullStr Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
title_full_unstemmed Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
title_short Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial
title_sort single high-dose vitamin d supplementation as an approach for reducing ultramarathon-induced inflammation: a double-blind randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069287/
https://www.ncbi.nlm.nih.gov/pubmed/33924645
http://dx.doi.org/10.3390/nu13041280
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