Cargando…
Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropom...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069327/ https://www.ncbi.nlm.nih.gov/pubmed/33921361 http://dx.doi.org/10.3390/life11040341 |
_version_ | 1783683211189026816 |
---|---|
author | Kałużna, Małgorzata Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Krzysztof Yusuf Ibrahim, Aisha Czlapka-Matyasik, Magdalena Wrotkowska, Elżbieta Ziemnicka, Katarzyna Oko, Andrzej Ruchała, Marek |
author_facet | Kałużna, Małgorzata Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Krzysztof Yusuf Ibrahim, Aisha Czlapka-Matyasik, Magdalena Wrotkowska, Elżbieta Ziemnicka, Katarzyna Oko, Andrzej Ruchała, Marek |
author_sort | Kałużna, Małgorzata |
collection | PubMed |
description | Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = −0.319, p = 0.009; r = −0.341, p = 0.005; r = −0.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p < 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients. |
format | Online Article Text |
id | pubmed-8069327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80693272021-04-26 Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? Kałużna, Małgorzata Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Krzysztof Yusuf Ibrahim, Aisha Czlapka-Matyasik, Magdalena Wrotkowska, Elżbieta Ziemnicka, Katarzyna Oko, Andrzej Ruchała, Marek Life (Basel) Article Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = −0.319, p = 0.009; r = −0.341, p = 0.005; r = −0.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p < 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients. MDPI 2021-04-12 /pmc/articles/PMC8069327/ /pubmed/33921361 http://dx.doi.org/10.3390/life11040341 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kałużna, Małgorzata Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Krzysztof Yusuf Ibrahim, Aisha Czlapka-Matyasik, Magdalena Wrotkowska, Elżbieta Ziemnicka, Katarzyna Oko, Andrzej Ruchała, Marek Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? |
title | Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? |
title_full | Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? |
title_fullStr | Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? |
title_full_unstemmed | Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? |
title_short | Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? |
title_sort | is preptin a new bone metabolism parameter in hemodialysis patients? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069327/ https://www.ncbi.nlm.nih.gov/pubmed/33921361 http://dx.doi.org/10.3390/life11040341 |
work_keys_str_mv | AT kałuznamałgorzata ispreptinanewbonemetabolismparameterinhemodialysispatients AT pawlaczykkrzysztof ispreptinanewbonemetabolismparameterinhemodialysispatients AT schwermerkrzysztof ispreptinanewbonemetabolismparameterinhemodialysispatients AT hoppekrzysztof ispreptinanewbonemetabolismparameterinhemodialysispatients AT yusufibrahimaisha ispreptinanewbonemetabolismparameterinhemodialysispatients AT czlapkamatyasikmagdalena ispreptinanewbonemetabolismparameterinhemodialysispatients AT wrotkowskaelzbieta ispreptinanewbonemetabolismparameterinhemodialysispatients AT ziemnickakatarzyna ispreptinanewbonemetabolismparameterinhemodialysispatients AT okoandrzej ispreptinanewbonemetabolismparameterinhemodialysispatients AT ruchałamarek ispreptinanewbonemetabolismparameterinhemodialysispatients |