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Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?

Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropom...

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Autores principales: Kałużna, Małgorzata, Pawlaczyk, Krzysztof, Schwermer, Krzysztof, Hoppe, Krzysztof, Yusuf Ibrahim, Aisha, Czlapka-Matyasik, Magdalena, Wrotkowska, Elżbieta, Ziemnicka, Katarzyna, Oko, Andrzej, Ruchała, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069327/
https://www.ncbi.nlm.nih.gov/pubmed/33921361
http://dx.doi.org/10.3390/life11040341
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author Kałużna, Małgorzata
Pawlaczyk, Krzysztof
Schwermer, Krzysztof
Hoppe, Krzysztof
Yusuf Ibrahim, Aisha
Czlapka-Matyasik, Magdalena
Wrotkowska, Elżbieta
Ziemnicka, Katarzyna
Oko, Andrzej
Ruchała, Marek
author_facet Kałużna, Małgorzata
Pawlaczyk, Krzysztof
Schwermer, Krzysztof
Hoppe, Krzysztof
Yusuf Ibrahim, Aisha
Czlapka-Matyasik, Magdalena
Wrotkowska, Elżbieta
Ziemnicka, Katarzyna
Oko, Andrzej
Ruchała, Marek
author_sort Kałużna, Małgorzata
collection PubMed
description Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = −0.319, p = 0.009; r = −0.341, p = 0.005; r = −0.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p < 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients.
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spelling pubmed-80693272021-04-26 Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients? Kałużna, Małgorzata Pawlaczyk, Krzysztof Schwermer, Krzysztof Hoppe, Krzysztof Yusuf Ibrahim, Aisha Czlapka-Matyasik, Magdalena Wrotkowska, Elżbieta Ziemnicka, Katarzyna Oko, Andrzej Ruchała, Marek Life (Basel) Article Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = −0.319, p = 0.009; r = −0.341, p = 0.005; r = −0.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p < 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients. MDPI 2021-04-12 /pmc/articles/PMC8069327/ /pubmed/33921361 http://dx.doi.org/10.3390/life11040341 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kałużna, Małgorzata
Pawlaczyk, Krzysztof
Schwermer, Krzysztof
Hoppe, Krzysztof
Yusuf Ibrahim, Aisha
Czlapka-Matyasik, Magdalena
Wrotkowska, Elżbieta
Ziemnicka, Katarzyna
Oko, Andrzej
Ruchała, Marek
Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
title Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
title_full Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
title_fullStr Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
title_full_unstemmed Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
title_short Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?
title_sort is preptin a new bone metabolism parameter in hemodialysis patients?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069327/
https://www.ncbi.nlm.nih.gov/pubmed/33921361
http://dx.doi.org/10.3390/life11040341
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