Cargando…

Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy

Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow’s milk protein allergy (CMPA) and for monitoring the infants’ response to a non-IgE mediated cow’s milk protein (CMP)-free diet. We prospectively recruited infant...

Descripción completa

Detalles Bibliográficos
Autores principales: Roca, María, Donat, Ester, Rodriguez Varela, Ana, Carvajal, Eva, Cano, Francisco, Armisen, Ana, Ekoff, Helena, Cañada-Martínez, Antonio José, Rydell, Niclas, Ribes-Koninckx, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069369/
https://www.ncbi.nlm.nih.gov/pubmed/33918903
http://dx.doi.org/10.3390/jcm10081595
_version_ 1783683221114847232
author Roca, María
Donat, Ester
Rodriguez Varela, Ana
Carvajal, Eva
Cano, Francisco
Armisen, Ana
Ekoff, Helena
Cañada-Martínez, Antonio José
Rydell, Niclas
Ribes-Koninckx, Carmen
author_facet Roca, María
Donat, Ester
Rodriguez Varela, Ana
Carvajal, Eva
Cano, Francisco
Armisen, Ana
Ekoff, Helena
Cañada-Martínez, Antonio José
Rydell, Niclas
Ribes-Koninckx, Carmen
author_sort Roca, María
collection PubMed
description Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow’s milk protein allergy (CMPA) and for monitoring the infants’ response to a non-IgE mediated cow’s milk protein (CMP)-free diet. We prospectively recruited infants aged 0 to 9 months. Stool samples were taken from 30 infants with CMPA, 19 with mild functional gastrointestinal disorders, 28 healthy infants, and 28 children who presented mild infections. Despite the fact that levels of fCP and fEDN in CMPA infants were higher than in healthy infants at month 0, differences for both parameters did not reach statistical significance (p-value 0.119 and 0.506). After 1 month of an elimination diet, no statistically significant differences in fCP with basal levels were found (p-values 0.184) in the CMPA group. We found a high variability in the fCP and fEDN levels of young infants, and discrepancies in individual behavior of these markers after a CMP-free diet was started. It seems that neither fCP nor fEDN levels are helpful to discriminate between healthy infants and those with signs or symptoms related to non-IgE-mediated CMPA. Additionally, it is debatable if on an individual basis, fCP or fEDN levels could be used for clinical follow-up and dietary compliance monitoring. However, prospective studies with larger populations are needed to draw robust conclusions.
format Online
Article
Text
id pubmed-8069369
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80693692021-04-26 Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy Roca, María Donat, Ester Rodriguez Varela, Ana Carvajal, Eva Cano, Francisco Armisen, Ana Ekoff, Helena Cañada-Martínez, Antonio José Rydell, Niclas Ribes-Koninckx, Carmen J Clin Med Article Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow’s milk protein allergy (CMPA) and for monitoring the infants’ response to a non-IgE mediated cow’s milk protein (CMP)-free diet. We prospectively recruited infants aged 0 to 9 months. Stool samples were taken from 30 infants with CMPA, 19 with mild functional gastrointestinal disorders, 28 healthy infants, and 28 children who presented mild infections. Despite the fact that levels of fCP and fEDN in CMPA infants were higher than in healthy infants at month 0, differences for both parameters did not reach statistical significance (p-value 0.119 and 0.506). After 1 month of an elimination diet, no statistically significant differences in fCP with basal levels were found (p-values 0.184) in the CMPA group. We found a high variability in the fCP and fEDN levels of young infants, and discrepancies in individual behavior of these markers after a CMP-free diet was started. It seems that neither fCP nor fEDN levels are helpful to discriminate between healthy infants and those with signs or symptoms related to non-IgE-mediated CMPA. Additionally, it is debatable if on an individual basis, fCP or fEDN levels could be used for clinical follow-up and dietary compliance monitoring. However, prospective studies with larger populations are needed to draw robust conclusions. MDPI 2021-04-09 /pmc/articles/PMC8069369/ /pubmed/33918903 http://dx.doi.org/10.3390/jcm10081595 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Roca, María
Donat, Ester
Rodriguez Varela, Ana
Carvajal, Eva
Cano, Francisco
Armisen, Ana
Ekoff, Helena
Cañada-Martínez, Antonio José
Rydell, Niclas
Ribes-Koninckx, Carmen
Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy
title Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy
title_full Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy
title_fullStr Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy
title_full_unstemmed Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy
title_short Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy
title_sort fecal calprotectin and eosinophil-derived neurotoxin in children with non-ige-mediated cow’s milk protein allergy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069369/
https://www.ncbi.nlm.nih.gov/pubmed/33918903
http://dx.doi.org/10.3390/jcm10081595
work_keys_str_mv AT rocamaria fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT donatester fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT rodriguezvarelaana fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT carvajaleva fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT canofrancisco fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT armisenana fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT ekoffhelena fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT canadamartinezantoniojose fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT rydellniclas fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy
AT ribeskoninckxcarmen fecalcalprotectinandeosinophilderivedneurotoxininchildrenwithnonigemediatedcowsmilkproteinallergy