Cargando…

Sinularin, an Anti-Cancer Agent Causing Mitochondria-Modulated Apoptosis and Cytoskeleton Disruption in Human Hepatocellular Carcinoma

Liver cancer remains a leading cause of death, despite advances in anti-cancer therapies. To develop novel drugs, natural products are being considered as a good source for exploration. In this study, a natural product isolated from a soft coral was applied to evaluate its anti-cancer activities in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ko, Chou-Yuan, Shih, Po-Chang, Huang, Po-Wei, Lee, Yi-Hsin, Chen, Yen-Fu, Tai, Ming-Hong, Liu, Chi-Hao, Wen, Zhi-Hong, Kuo, Hsiao-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069418/ https://www.ncbi.nlm.nih.gov/pubmed/33920454 http://dx.doi.org/10.3390/ijms22083946

Ejemplares similares

Sinularin Induces Oxidative Stress-Mediated Apoptosis and Mitochondrial Dysfunction, and Inhibits Angiogenesis in Glioblastoma Cells
por: Hsu, Shih-Yuan, et al.
Publicado: (2022)

Sinularin induces DNA damage, G2/M phase arrest, and apoptosis in human hepatocellular carcinoma cells
por: Chung, Ting-Wen, et al.
Publicado: (2017)

Sinularin Induces Apoptosis through Mitochondria Dysfunction and Inactivation of the pI3K/Akt/mTOR Pathway in Gastric Carcinoma Cells
por: Wu, Yu-Jen, et al.
Publicado: (2016)

Comparison of Antioxidant and Anticancer Properties of Soft Coral-Derived Sinularin and Dihydrosinularin
por: Wang, Sheng-Chieh, et al.
Publicado: (2021)

Pardaxin Activates Excessive Mitophagy and Mitochondria-Mediated Apoptosis in Human Ovarian Cancer by Inducing Reactive Oxygen Species
por: Chen, Yen-Po, et al.
Publicado: (2021)

Sinularin from Indigenous Soft Coral Attenuates Nociceptive Responses and Spinal Neuroinflammation in Carrageenan-Induced Inflammatory Rat Model
por: Huang, Shi-Ying, et al.
Publicado: (2012)

Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage
por: Huang, Hurng-Wern, et al.
Publicado: (2018)

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells
por: Peng, Sheng-Yao, et al.
Publicado: (2021)

Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton
por: Kim, Sujeong, et al.
Publicado: (2012)

Sinularin exerts anti-tumor effects against human renal cancer cells relies on the generation of ROS
por: Ma, Qi, et al.
Publicado: (2019)

The Interactive Effects of Cytoskeleton Disruption and Mitochondria Dysfunction Lead to Reproductive Toxicity Induced by Microcystin-LR
por: Chen, Liang, et al.
Publicado: (2013)

Mitochondria-cytoskeleton associations in mammalian cytokinesis
por: Lawrence, E. J., et al.
Publicado: (2016)

Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
por: Cardanho‐Ramos, Carlos, et al.
Publicado: (2019)

Motor proteins at the mitochondria–cytoskeleton interface
por: Kruppa, Antonina J., et al.
Publicado: (2021)

Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer
por: Hong, Taeyeon, et al.
Publicado: (2022)

Structural Heterogeneity of Mitochondria Induced by the Microtubule Cytoskeleton
por: Sukhorukov, Valerii M., et al.
Publicado: (2015)

Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells
por: Kuznetsov, Andrey V., et al.
Publicado: (2020)

RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal
por: Huang, Zongshun, et al.
Publicado: (2016)

Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers
por: Chou, Pei-Hsin, et al.
Publicado: (2019)

Disruption of Cytosolic Folate Integrity Aggravates Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Modulates Metastatic Properties in Non-Small-Cell Lung Cancer Cells
por: Shen, Po-Wen, et al.
Publicado: (2021)

Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria
por: Alberti, Paola, et al.
Publicado: (2022)

Actin-Cytoskeleton Drives Caveolae Signaling to Mitochondria during Postconditioning
por: Correa, Francisco, et al.
Publicado: (2023)

Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes
por: Fan, Letao, et al.
Publicado: (2023)

Synergistic Effect of Combination of a Temoporfin-Based Photodynamic Therapy with Potassium Iodide or Antibacterial Agents on Oral Disease Pathogens In Vitro
por: Shih, Yin-Hwa, et al.
Publicado: (2022)

MSP-4, an Antimicrobial Peptide, Induces Apoptosis via Activation of Extrinsic Fas/FasL- and Intrinsic Mitochondria-Mediated Pathways in One Osteosarcoma Cell Line
por: Kuo, Hsiao-Mei, et al.
Publicado: (2018)

Correction: Huang, H.W.; et al. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage. Molecules 2018, 23, 849
por: Huang, Hurng-Wern, et al.
Publicado: (2018)

Indocyanine green as a near-infrared theranostic agent for ferroptosis and apoptosis-based, photothermal, and photodynamic cancer therapy
por: Tseng, Hsiang-Ching, et al.
Publicado: (2022)

Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity
por: Pessoa-Pureur, Regina, et al.
Publicado: (2014)

Oxidative stress disrupts the cytoskeleton of spinal motor neurons
por: Chen, Jian, et al.
Publicado: (2022)

Apoptosis in platelets is independent of the actin cytoskeleton
por: De Silva, Enoli, et al.
Publicado: (2022)

Synergistic Effects of DNA and Cytoskeleton Damage-Inducing Agents on Apoptosis in Human Tumor Cell Lines
por: Shang, Xueyuan, et al.
Publicado: (2001)

A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells
por: Ho, Chun-Te, et al.
Publicado: (2015)

Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo
por: Tsai, Cheng-Hsuan, et al.
Publicado: (2021)

Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells
por: Zhuo, Ye Hong, et al.
Publicado: (2010)

Proteomics Analysis Reveals the Implications of Cytoskeleton and Mitochondria in the Response of the Rat Brain to Starvation
por: Cuevas-Fernández, Beatriz, et al.
Publicado: (2019)

Inflammatory cytokines associated with cancer growth induce mitochondria and cytoskeleton alterations in cardiomyocytes
por: Buoncervello, Maria, et al.
Publicado: (2019)

Identification of a modulator of the actin cytoskeleton, mitochondria, nutrient metabolism and lifespan in yeast
por: Sing, Cierra N., et al.
Publicado: (2022)

Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton
Publicado: (1984)

Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment
por: Hevia, Lorena García, et al.
Publicado: (2020)

Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide
por: Hahm, Eun-Ryeong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mepo4tvl0vq9pn09bmokn44p15