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Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season

While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used n...

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Autores principales: Pando, Rakefet, Stern, Shahar, Nemet, Ital, Glatman-Freedman, Aharona, Sefty, Hanna, Zuckerman, Neta S., Drori, Yaron, Friedman, Nehemya, McCauley, John W., Keinan-Boker, Lital, Mendelson, Ella, Daniels, Rodney S., Mandelboim, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069444/
https://www.ncbi.nlm.nih.gov/pubmed/33924296
http://dx.doi.org/10.3390/vaccines9040375
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author Pando, Rakefet
Stern, Shahar
Nemet, Ital
Glatman-Freedman, Aharona
Sefty, Hanna
Zuckerman, Neta S.
Drori, Yaron
Friedman, Nehemya
McCauley, John W.
Keinan-Boker, Lital
Mendelson, Ella
Daniels, Rodney S.
Mandelboim, Michal
author_facet Pando, Rakefet
Stern, Shahar
Nemet, Ital
Glatman-Freedman, Aharona
Sefty, Hanna
Zuckerman, Neta S.
Drori, Yaron
Friedman, Nehemya
McCauley, John W.
Keinan-Boker, Lital
Mendelson, Ella
Daniels, Rodney S.
Mandelboim, Michal
author_sort Pando, Rakefet
collection PubMed
description While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines.
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spelling pubmed-80694442021-04-26 Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season Pando, Rakefet Stern, Shahar Nemet, Ital Glatman-Freedman, Aharona Sefty, Hanna Zuckerman, Neta S. Drori, Yaron Friedman, Nehemya McCauley, John W. Keinan-Boker, Lital Mendelson, Ella Daniels, Rodney S. Mandelboim, Michal Vaccines (Basel) Article While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines. MDPI 2021-04-13 /pmc/articles/PMC8069444/ /pubmed/33924296 http://dx.doi.org/10.3390/vaccines9040375 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pando, Rakefet
Stern, Shahar
Nemet, Ital
Glatman-Freedman, Aharona
Sefty, Hanna
Zuckerman, Neta S.
Drori, Yaron
Friedman, Nehemya
McCauley, John W.
Keinan-Boker, Lital
Mendelson, Ella
Daniels, Rodney S.
Mandelboim, Michal
Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
title Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
title_full Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
title_fullStr Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
title_full_unstemmed Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
title_short Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
title_sort diversity in the circulation of influenza a(h3n2) viruses in the northern hemisphere in the 2018–19 season
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069444/
https://www.ncbi.nlm.nih.gov/pubmed/33924296
http://dx.doi.org/10.3390/vaccines9040375
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