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Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season
While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used n...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069444/ https://www.ncbi.nlm.nih.gov/pubmed/33924296 http://dx.doi.org/10.3390/vaccines9040375 |
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author | Pando, Rakefet Stern, Shahar Nemet, Ital Glatman-Freedman, Aharona Sefty, Hanna Zuckerman, Neta S. Drori, Yaron Friedman, Nehemya McCauley, John W. Keinan-Boker, Lital Mendelson, Ella Daniels, Rodney S. Mandelboim, Michal |
author_facet | Pando, Rakefet Stern, Shahar Nemet, Ital Glatman-Freedman, Aharona Sefty, Hanna Zuckerman, Neta S. Drori, Yaron Friedman, Nehemya McCauley, John W. Keinan-Boker, Lital Mendelson, Ella Daniels, Rodney S. Mandelboim, Michal |
author_sort | Pando, Rakefet |
collection | PubMed |
description | While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines. |
format | Online Article Text |
id | pubmed-8069444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80694442021-04-26 Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season Pando, Rakefet Stern, Shahar Nemet, Ital Glatman-Freedman, Aharona Sefty, Hanna Zuckerman, Neta S. Drori, Yaron Friedman, Nehemya McCauley, John W. Keinan-Boker, Lital Mendelson, Ella Daniels, Rodney S. Mandelboim, Michal Vaccines (Basel) Article While vaccination is considered the most effective means to prevent influenza infection, its seasonal effectiveness varies, depending on the circulating influenza strains. Here, we characterized the circulation of influenza strains in October-2018 and March-2019 around the world. For this, we used nasopharyngeal samples collected from outpatient and hospitalized patients in Israel and data reported in ECDC, CDC, and WHO databases. Influenza A(H3N2) was dominant in Israel, while in Europe, Asia, and USA, A(H1N1)pdm09 virus circulated first, and then the A(H3N2) virus also appeared. Phylogenetic analysis indicated that A(H3N2) viruses circulating in Israel belonged to clade-3C.3a, while in Europe, Asia, and USA, A(H3N2) viruses belonged to subclade-3C.2a1, but were later replaced by clade-3C.3a viruses in USA. The vaccine A(H3N2) components of that year, A/Singapore/INFIMH-16-0019/2016-(H3N2)-like-viruses, belonged to clade-3C.2a1. The circulation of different influenza subtypes and clades of A(H3N2) viruses in a single season highlights the need for universal influenza vaccines. MDPI 2021-04-13 /pmc/articles/PMC8069444/ /pubmed/33924296 http://dx.doi.org/10.3390/vaccines9040375 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pando, Rakefet Stern, Shahar Nemet, Ital Glatman-Freedman, Aharona Sefty, Hanna Zuckerman, Neta S. Drori, Yaron Friedman, Nehemya McCauley, John W. Keinan-Boker, Lital Mendelson, Ella Daniels, Rodney S. Mandelboim, Michal Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
title | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
title_full | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
title_fullStr | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
title_full_unstemmed | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
title_short | Diversity in the Circulation of Influenza A(H3N2) Viruses in the Northern Hemisphere in the 2018–19 Season |
title_sort | diversity in the circulation of influenza a(h3n2) viruses in the northern hemisphere in the 2018–19 season |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069444/ https://www.ncbi.nlm.nih.gov/pubmed/33924296 http://dx.doi.org/10.3390/vaccines9040375 |
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