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DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in...

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Autores principales: Tukhovskaya, Elena A., Shaykhutdinova, Elvira R., Ismailova, Alina M., Slashcheva, Gulsara A., Prudchenko, Igor A., Mikhaleva, Inessa I., Khokhlova, Oksana N., Murashev, Arkady N., Ivanov, Vadim T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069497/
https://www.ncbi.nlm.nih.gov/pubmed/33918965
http://dx.doi.org/10.3390/biomedicines9040407
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author Tukhovskaya, Elena A.
Shaykhutdinova, Elvira R.
Ismailova, Alina M.
Slashcheva, Gulsara A.
Prudchenko, Igor A.
Mikhaleva, Inessa I.
Khokhlova, Oksana N.
Murashev, Arkady N.
Ivanov, Vadim T.
author_facet Tukhovskaya, Elena A.
Shaykhutdinova, Elvira R.
Ismailova, Alina M.
Slashcheva, Gulsara A.
Prudchenko, Igor A.
Mikhaleva, Inessa I.
Khokhlova, Oksana N.
Murashev, Arkady N.
Ivanov, Vadim T.
author_sort Tukhovskaya, Elena A.
collection PubMed
description A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.
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spelling pubmed-80694972021-04-26 DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion Tukhovskaya, Elena A. Shaykhutdinova, Elvira R. Ismailova, Alina M. Slashcheva, Gulsara A. Prudchenko, Igor A. Mikhaleva, Inessa I. Khokhlova, Oksana N. Murashev, Arkady N. Ivanov, Vadim T. Biomedicines Article A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion. MDPI 2021-04-09 /pmc/articles/PMC8069497/ /pubmed/33918965 http://dx.doi.org/10.3390/biomedicines9040407 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tukhovskaya, Elena A.
Shaykhutdinova, Elvira R.
Ismailova, Alina M.
Slashcheva, Gulsara A.
Prudchenko, Igor A.
Mikhaleva, Inessa I.
Khokhlova, Oksana N.
Murashev, Arkady N.
Ivanov, Vadim T.
DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion
title DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion
title_full DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion
title_fullStr DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion
title_full_unstemmed DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion
title_short DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion
title_sort dsip-like knd peptide reduces brain infarction in c57bl/6 and reduces myocardial infarction in sd rats when administered during reperfusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069497/
https://www.ncbi.nlm.nih.gov/pubmed/33918965
http://dx.doi.org/10.3390/biomedicines9040407
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