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Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and s...

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Autores principales: Lee, Thung-Lip, Hsuan, Chin-Feng, Wu, Cheng-Ching, Hung, Wei-Chin, Tsai, I-Ting, Wei, Ching-Ting, Yu, Teng-Hung, Lu, I-Cheng, Chung, Fu-Mei, Lee, Yau-Jiunn, Lu, Yung-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069503/
https://www.ncbi.nlm.nih.gov/pubmed/33921213
http://dx.doi.org/10.3390/ijerph18084020
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author Lee, Thung-Lip
Hsuan, Chin-Feng
Wu, Cheng-Ching
Hung, Wei-Chin
Tsai, I-Ting
Wei, Ching-Ting
Yu, Teng-Hung
Lu, I-Cheng
Chung, Fu-Mei
Lee, Yau-Jiunn
Lu, Yung-Chuan
author_facet Lee, Thung-Lip
Hsuan, Chin-Feng
Wu, Cheng-Ching
Hung, Wei-Chin
Tsai, I-Ting
Wei, Ching-Ting
Yu, Teng-Hung
Lu, I-Cheng
Chung, Fu-Mei
Lee, Yau-Jiunn
Lu, Yung-Chuan
author_sort Lee, Thung-Lip
collection PubMed
description Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and sudden cardiac death, and a high prevalence of prolonged QTc interval was previously reported in blue-collar workers. The purpose of this study was to find the possible causal inter-relationship between TyG index and QTc interval in a large population of Chinese male steelworkers. Methods: A total of 3189 male workers from two steel plants were enrolled. They responded to a cross-sectional questionnaire on basic attributes and lifestyle, including sleep patterns. All workers in the two plants underwent periodic health checkups, including twelve-lead electrocardiography. Structural equation modeling (SEM) was used to assess the direct and indirect effects of TyG index on QTc interval. Results: With increasing TyG index tertile, the male steelworkers had an increased QTc interval. Applying multivariate analysis, TyG index was associated independently with the odds of QTc prolongation (adjusted odds ratio = 2.73, 95% confidence interval = 1.39–5.24, p = 0.004). SEM revealed that TyG index, hypertension, obesity, lifestyle, white blood cell (WBC) count, and liver function had statistically significant direct effects on QTc interval. Furthermore, TyG index also had an indirect effect on QTc interval through hypertension, obesity, WBC count, and liver function. Moreover, lifestyle had an indirect effect on QTc interval through TyG index. The final model explained 14% of the variability in QTc interval. Conclusions: An increased TyG index was associated with QTc interval prolongation in this study, and SEM delineated possible causal pathways and inter-relationships of the risk factors contributing to the occurrence of QTc prolongation among Chinese male steelworkers.
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spelling pubmed-80695032021-04-26 Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers Lee, Thung-Lip Hsuan, Chin-Feng Wu, Cheng-Ching Hung, Wei-Chin Tsai, I-Ting Wei, Ching-Ting Yu, Teng-Hung Lu, I-Cheng Chung, Fu-Mei Lee, Yau-Jiunn Lu, Yung-Chuan Int J Environ Res Public Health Article Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and sudden cardiac death, and a high prevalence of prolonged QTc interval was previously reported in blue-collar workers. The purpose of this study was to find the possible causal inter-relationship between TyG index and QTc interval in a large population of Chinese male steelworkers. Methods: A total of 3189 male workers from two steel plants were enrolled. They responded to a cross-sectional questionnaire on basic attributes and lifestyle, including sleep patterns. All workers in the two plants underwent periodic health checkups, including twelve-lead electrocardiography. Structural equation modeling (SEM) was used to assess the direct and indirect effects of TyG index on QTc interval. Results: With increasing TyG index tertile, the male steelworkers had an increased QTc interval. Applying multivariate analysis, TyG index was associated independently with the odds of QTc prolongation (adjusted odds ratio = 2.73, 95% confidence interval = 1.39–5.24, p = 0.004). SEM revealed that TyG index, hypertension, obesity, lifestyle, white blood cell (WBC) count, and liver function had statistically significant direct effects on QTc interval. Furthermore, TyG index also had an indirect effect on QTc interval through hypertension, obesity, WBC count, and liver function. Moreover, lifestyle had an indirect effect on QTc interval through TyG index. The final model explained 14% of the variability in QTc interval. Conclusions: An increased TyG index was associated with QTc interval prolongation in this study, and SEM delineated possible causal pathways and inter-relationships of the risk factors contributing to the occurrence of QTc prolongation among Chinese male steelworkers. MDPI 2021-04-12 /pmc/articles/PMC8069503/ /pubmed/33921213 http://dx.doi.org/10.3390/ijerph18084020 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Thung-Lip
Hsuan, Chin-Feng
Wu, Cheng-Ching
Hung, Wei-Chin
Tsai, I-Ting
Wei, Ching-Ting
Yu, Teng-Hung
Lu, I-Cheng
Chung, Fu-Mei
Lee, Yau-Jiunn
Lu, Yung-Chuan
Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers
title Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers
title_full Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers
title_fullStr Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers
title_full_unstemmed Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers
title_short Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers
title_sort association between triglyceride glucose index and corrected qt prolongation in chinese male steelworkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069503/
https://www.ncbi.nlm.nih.gov/pubmed/33921213
http://dx.doi.org/10.3390/ijerph18084020
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