Cargando…

The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements

Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair. With growing interest in RNA biology, increasing RNAs...

Descripción completa

Detalles Bibliográficos
Autores principales: Murashko, Matvey Mikhailovich, Stasevich, Ekaterina Mikhailovna, Schwartz, Anton Markovich, Kuprash, Dmitriy Vladimirovich, Uvarova, Aksinya Nicolaevna, Demin, Denis Eriksonovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069526/
https://www.ncbi.nlm.nih.gov/pubmed/33918762
http://dx.doi.org/10.3390/biom11040550
_version_ 1783683257924059136
author Murashko, Matvey Mikhailovich
Stasevich, Ekaterina Mikhailovna
Schwartz, Anton Markovich
Kuprash, Dmitriy Vladimirovich
Uvarova, Aksinya Nicolaevna
Demin, Denis Eriksonovich
author_facet Murashko, Matvey Mikhailovich
Stasevich, Ekaterina Mikhailovna
Schwartz, Anton Markovich
Kuprash, Dmitriy Vladimirovich
Uvarova, Aksinya Nicolaevna
Demin, Denis Eriksonovich
author_sort Murashko, Matvey Mikhailovich
collection PubMed
description Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair. With growing interest in RNA biology, increasing RNAs are classified as crucial at the different stages of the main pathways of DSB repair in eukaryotic cells: nonhomologous end joining (NHEJ) and homology-directed repair (HDR). Gene mutations or variation in expression levels of such RNAs can lead to local DNA repair defects, increasing the chromosome aberration frequency. Moreover, it was demonstrated that some RNAs could stimulate long-range chromosomal rearrangements. In this review, we discuss recent evidence demonstrating the role of various RNAs in DSB formation and repair. We also consider how RNA may mediate certain chromosomal rearrangements in a sequence-specific manner.
format Online
Article
Text
id pubmed-8069526
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80695262021-04-26 The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements Murashko, Matvey Mikhailovich Stasevich, Ekaterina Mikhailovna Schwartz, Anton Markovich Kuprash, Dmitriy Vladimirovich Uvarova, Aksinya Nicolaevna Demin, Denis Eriksonovich Biomolecules Review Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair. With growing interest in RNA biology, increasing RNAs are classified as crucial at the different stages of the main pathways of DSB repair in eukaryotic cells: nonhomologous end joining (NHEJ) and homology-directed repair (HDR). Gene mutations or variation in expression levels of such RNAs can lead to local DNA repair defects, increasing the chromosome aberration frequency. Moreover, it was demonstrated that some RNAs could stimulate long-range chromosomal rearrangements. In this review, we discuss recent evidence demonstrating the role of various RNAs in DSB formation and repair. We also consider how RNA may mediate certain chromosomal rearrangements in a sequence-specific manner. MDPI 2021-04-09 /pmc/articles/PMC8069526/ /pubmed/33918762 http://dx.doi.org/10.3390/biom11040550 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Murashko, Matvey Mikhailovich
Stasevich, Ekaterina Mikhailovna
Schwartz, Anton Markovich
Kuprash, Dmitriy Vladimirovich
Uvarova, Aksinya Nicolaevna
Demin, Denis Eriksonovich
The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
title The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
title_full The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
title_fullStr The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
title_full_unstemmed The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
title_short The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
title_sort role of rna in dna breaks, repair and chromosomal rearrangements
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069526/
https://www.ncbi.nlm.nih.gov/pubmed/33918762
http://dx.doi.org/10.3390/biom11040550
work_keys_str_mv AT murashkomatveymikhailovich theroleofrnaindnabreaksrepairandchromosomalrearrangements
AT stasevichekaterinamikhailovna theroleofrnaindnabreaksrepairandchromosomalrearrangements
AT schwartzantonmarkovich theroleofrnaindnabreaksrepairandchromosomalrearrangements
AT kuprashdmitriyvladimirovich theroleofrnaindnabreaksrepairandchromosomalrearrangements
AT uvarovaaksinyanicolaevna theroleofrnaindnabreaksrepairandchromosomalrearrangements
AT demindeniseriksonovich theroleofrnaindnabreaksrepairandchromosomalrearrangements
AT murashkomatveymikhailovich roleofrnaindnabreaksrepairandchromosomalrearrangements
AT stasevichekaterinamikhailovna roleofrnaindnabreaksrepairandchromosomalrearrangements
AT schwartzantonmarkovich roleofrnaindnabreaksrepairandchromosomalrearrangements
AT kuprashdmitriyvladimirovich roleofrnaindnabreaksrepairandchromosomalrearrangements
AT uvarovaaksinyanicolaevna roleofrnaindnabreaksrepairandchromosomalrearrangements
AT demindeniseriksonovich roleofrnaindnabreaksrepairandchromosomalrearrangements