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The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair. With growing interest in RNA biology, increasing RNAs...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069526/ https://www.ncbi.nlm.nih.gov/pubmed/33918762 http://dx.doi.org/10.3390/biom11040550 |
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author | Murashko, Matvey Mikhailovich Stasevich, Ekaterina Mikhailovna Schwartz, Anton Markovich Kuprash, Dmitriy Vladimirovich Uvarova, Aksinya Nicolaevna Demin, Denis Eriksonovich |
author_facet | Murashko, Matvey Mikhailovich Stasevich, Ekaterina Mikhailovna Schwartz, Anton Markovich Kuprash, Dmitriy Vladimirovich Uvarova, Aksinya Nicolaevna Demin, Denis Eriksonovich |
author_sort | Murashko, Matvey Mikhailovich |
collection | PubMed |
description | Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair. With growing interest in RNA biology, increasing RNAs are classified as crucial at the different stages of the main pathways of DSB repair in eukaryotic cells: nonhomologous end joining (NHEJ) and homology-directed repair (HDR). Gene mutations or variation in expression levels of such RNAs can lead to local DNA repair defects, increasing the chromosome aberration frequency. Moreover, it was demonstrated that some RNAs could stimulate long-range chromosomal rearrangements. In this review, we discuss recent evidence demonstrating the role of various RNAs in DSB formation and repair. We also consider how RNA may mediate certain chromosomal rearrangements in a sequence-specific manner. |
format | Online Article Text |
id | pubmed-8069526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80695262021-04-26 The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements Murashko, Matvey Mikhailovich Stasevich, Ekaterina Mikhailovna Schwartz, Anton Markovich Kuprash, Dmitriy Vladimirovich Uvarova, Aksinya Nicolaevna Demin, Denis Eriksonovich Biomolecules Review Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair. With growing interest in RNA biology, increasing RNAs are classified as crucial at the different stages of the main pathways of DSB repair in eukaryotic cells: nonhomologous end joining (NHEJ) and homology-directed repair (HDR). Gene mutations or variation in expression levels of such RNAs can lead to local DNA repair defects, increasing the chromosome aberration frequency. Moreover, it was demonstrated that some RNAs could stimulate long-range chromosomal rearrangements. In this review, we discuss recent evidence demonstrating the role of various RNAs in DSB formation and repair. We also consider how RNA may mediate certain chromosomal rearrangements in a sequence-specific manner. MDPI 2021-04-09 /pmc/articles/PMC8069526/ /pubmed/33918762 http://dx.doi.org/10.3390/biom11040550 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Murashko, Matvey Mikhailovich Stasevich, Ekaterina Mikhailovna Schwartz, Anton Markovich Kuprash, Dmitriy Vladimirovich Uvarova, Aksinya Nicolaevna Demin, Denis Eriksonovich The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements |
title | The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements |
title_full | The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements |
title_fullStr | The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements |
title_full_unstemmed | The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements |
title_short | The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements |
title_sort | role of rna in dna breaks, repair and chromosomal rearrangements |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069526/ https://www.ncbi.nlm.nih.gov/pubmed/33918762 http://dx.doi.org/10.3390/biom11040550 |
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