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Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions

Prostate cancer is a very common disease, which is, unfortunately, often the cause of many male deaths. This is underlined by the fact that the early stages of prostate cancer are often asymptomatic. Therefore, the disease is usually detected and diagnosed at late advanced or even metastasized stage...

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Autores principales: Kvízová, Jana, Pavlíčková, Vladimíra, Kmoníčková, Eva, Ruml, Tomáš, Rimpelová, Silvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069564/
https://www.ncbi.nlm.nih.gov/pubmed/33921501
http://dx.doi.org/10.3390/molecules26082228
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author Kvízová, Jana
Pavlíčková, Vladimíra
Kmoníčková, Eva
Ruml, Tomáš
Rimpelová, Silvie
author_facet Kvízová, Jana
Pavlíčková, Vladimíra
Kmoníčková, Eva
Ruml, Tomáš
Rimpelová, Silvie
author_sort Kvízová, Jana
collection PubMed
description Prostate cancer is a very common disease, which is, unfortunately, often the cause of many male deaths. This is underlined by the fact that the early stages of prostate cancer are often asymptomatic. Therefore, the disease is usually detected and diagnosed at late advanced or even metastasized stages, which are already difficult to treat. Hence, it is important to pursue research and development not only in terms of novel diagnostic methods but also of therapeutic ones, as well as to increase the effectiveness of the treatment by combinational medicinal approach. Therefore, in this review article, we focus on recent approaches and novel potential tools for the treatment of advanced prostate cancer; these include not only androgen deprivation therapy, antiandrogen therapy, photodynamic therapy, photothermal therapy, immunotherapy, multimodal therapy, but also poly(ADP-ribose) polymerase, Akt and cyclin-dependent kinase inhibitors.
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spelling pubmed-80695642021-04-26 Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions Kvízová, Jana Pavlíčková, Vladimíra Kmoníčková, Eva Ruml, Tomáš Rimpelová, Silvie Molecules Review Prostate cancer is a very common disease, which is, unfortunately, often the cause of many male deaths. This is underlined by the fact that the early stages of prostate cancer are often asymptomatic. Therefore, the disease is usually detected and diagnosed at late advanced or even metastasized stages, which are already difficult to treat. Hence, it is important to pursue research and development not only in terms of novel diagnostic methods but also of therapeutic ones, as well as to increase the effectiveness of the treatment by combinational medicinal approach. Therefore, in this review article, we focus on recent approaches and novel potential tools for the treatment of advanced prostate cancer; these include not only androgen deprivation therapy, antiandrogen therapy, photodynamic therapy, photothermal therapy, immunotherapy, multimodal therapy, but also poly(ADP-ribose) polymerase, Akt and cyclin-dependent kinase inhibitors. MDPI 2021-04-12 /pmc/articles/PMC8069564/ /pubmed/33921501 http://dx.doi.org/10.3390/molecules26082228 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kvízová, Jana
Pavlíčková, Vladimíra
Kmoníčková, Eva
Ruml, Tomáš
Rimpelová, Silvie
Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions
title Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions
title_full Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions
title_fullStr Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions
title_full_unstemmed Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions
title_short Quo Vadis Advanced Prostate Cancer Therapy? Novel Treatment Perspectives and Possible Future Directions
title_sort quo vadis advanced prostate cancer therapy? novel treatment perspectives and possible future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069564/
https://www.ncbi.nlm.nih.gov/pubmed/33921501
http://dx.doi.org/10.3390/molecules26082228
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