Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma

SIMPLE SUMMARY: The SDF-1α/CXCR4 axis plays crucial roles in proliferation, survival, invasion, dissemination, and drug resistance in multiple myeloma. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and introduces the SDF-1α/CXCR4 axis-targeted therapies in...

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Autores principales: Ito, Shigeki, Sato, Tsuyoshi, Maeta, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069569/
https://www.ncbi.nlm.nih.gov/pubmed/33918655
http://dx.doi.org/10.3390/cancers13081793
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author Ito, Shigeki
Sato, Tsuyoshi
Maeta, Takahiro
author_facet Ito, Shigeki
Sato, Tsuyoshi
Maeta, Takahiro
author_sort Ito, Shigeki
collection PubMed
description SIMPLE SUMMARY: The SDF-1α/CXCR4 axis plays crucial roles in proliferation, survival, invasion, dissemination, and drug resistance in multiple myeloma. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and introduces the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma. ABSTRACT: The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.
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spelling pubmed-80695692021-04-26 Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma Ito, Shigeki Sato, Tsuyoshi Maeta, Takahiro Cancers (Basel) Review SIMPLE SUMMARY: The SDF-1α/CXCR4 axis plays crucial roles in proliferation, survival, invasion, dissemination, and drug resistance in multiple myeloma. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and introduces the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma. ABSTRACT: The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma. MDPI 2021-04-09 /pmc/articles/PMC8069569/ /pubmed/33918655 http://dx.doi.org/10.3390/cancers13081793 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ito, Shigeki
Sato, Tsuyoshi
Maeta, Takahiro
Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_full Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_fullStr Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_full_unstemmed Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_short Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
title_sort role and therapeutic targeting of sdf-1α/cxcr4 axis in multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069569/
https://www.ncbi.nlm.nih.gov/pubmed/33918655
http://dx.doi.org/10.3390/cancers13081793
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