A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

SIMPLE SUMMARY: Neuroblastoma is a devasting childhood cancer in which multiple copies (amplification) of the cancer-causing gene MYCN strongly predict poor outcome. Neuroblastomas are reliant on high levels of cellular components called polyamines for their growth and malignant behavior, and the ge...

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Detalles Bibliográficos
Autores principales: Gamble, Laura D., Purgato, Stefania, Henderson, Michelle J., Di Giacomo, Simone, Russell, Amanda J., Pigini, Paolo, Murray, Jayne, Valli, Emanuele, Milazzo, Giorgio, Giorgi, Federico M., Cowley, Mark, Ashton, Lesley J., Bhalshankar, Jaydutt, Schleiermacher, Gudrun, Rihani, Ali, Van Maerken, Tom, Vandesompele, Jo, Speleman, Frank, Versteeg, Rogier, Koster, Jan, Eggert, Angelika, Noguera, Rosa, Stallings, Raymond L., Tonini, Gian Paolo, Fong, Kwun, Vaksman, Zalman, Diskin, Sharon J., Maris, John M., London, Wendy B., Marshall, Glenn M., Ziegler, David S., Hogarty, Michael D., Perini, Giovanni, Norris, Murray D., Haber, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069650/
https://www.ncbi.nlm.nih.gov/pubmed/33918978
http://dx.doi.org/10.3390/cancers13081807

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