The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism

Signaling through GPR109a, the putative receptor for the endogenous ligand β-OH butyrate, inhibits adipose tissue lipolysis. Niacin, an anti-atherosclerotic drug that can induce insulin resistance, activates GPR109a at nM concentrations. GPR109a is not essential for niacin to improve serum lipid pro...

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Detalles Bibliográficos
Autores principales: Geisler, Caroline E., Miller, Kendra E., Ghimire, Susma, Renquist, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069761/
https://www.ncbi.nlm.nih.gov/pubmed/33924461
http://dx.doi.org/10.3390/ijms22084001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069761/
https://www.ncbi.nlm.nih.gov/pubmed/33924461
http://dx.doi.org/10.3390/ijms22084001

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