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Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk

The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD)...

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Autores principales: Hernández-Camba, Alejandro, Carrillo-Palau, Marta, Ramos, Laura, Hernández Alvarez-Buylla, Noemi, Alonso-Abreu, Inmaculada, Hernández-Pérez, Anjara, Vela, Milagros, Arranz, Laura, Hernández-Guerra, Manuel, González-Gay, Miguel Ángel, Ferraz-Amaro, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069809/
https://www.ncbi.nlm.nih.gov/pubmed/33924727
http://dx.doi.org/10.3390/jcm10081671
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author Hernández-Camba, Alejandro
Carrillo-Palau, Marta
Ramos, Laura
Hernández Alvarez-Buylla, Noemi
Alonso-Abreu, Inmaculada
Hernández-Pérez, Anjara
Vela, Milagros
Arranz, Laura
Hernández-Guerra, Manuel
González-Gay, Miguel Ángel
Ferraz-Amaro, Iván
author_facet Hernández-Camba, Alejandro
Carrillo-Palau, Marta
Ramos, Laura
Hernández Alvarez-Buylla, Noemi
Alonso-Abreu, Inmaculada
Hernández-Pérez, Anjara
Vela, Milagros
Arranz, Laura
Hernández-Guerra, Manuel
González-Gay, Miguel Ángel
Ferraz-Amaro, Iván
author_sort Hernández-Camba, Alejandro
collection PubMed
description The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification. After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, p = 0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (p = 0.034) were reclassified into the very high-CV-risk category. Disease-related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03 (95%CI 1.02–1.04) vs. 1.01 (95%CI 1.00–1.02), interaction p = 0.035) after adjustment for confounders. In conclusion, carotid plaque assessment is useful to identify high-CV risk IBD patients.
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spelling pubmed-80698092021-04-26 Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk Hernández-Camba, Alejandro Carrillo-Palau, Marta Ramos, Laura Hernández Alvarez-Buylla, Noemi Alonso-Abreu, Inmaculada Hernández-Pérez, Anjara Vela, Milagros Arranz, Laura Hernández-Guerra, Manuel González-Gay, Miguel Ángel Ferraz-Amaro, Iván J Clin Med Article The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification. After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, p = 0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (p = 0.034) were reclassified into the very high-CV-risk category. Disease-related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03 (95%CI 1.02–1.04) vs. 1.01 (95%CI 1.00–1.02), interaction p = 0.035) after adjustment for confounders. In conclusion, carotid plaque assessment is useful to identify high-CV risk IBD patients. MDPI 2021-04-13 /pmc/articles/PMC8069809/ /pubmed/33924727 http://dx.doi.org/10.3390/jcm10081671 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hernández-Camba, Alejandro
Carrillo-Palau, Marta
Ramos, Laura
Hernández Alvarez-Buylla, Noemi
Alonso-Abreu, Inmaculada
Hernández-Pérez, Anjara
Vela, Milagros
Arranz, Laura
Hernández-Guerra, Manuel
González-Gay, Miguel Ángel
Ferraz-Amaro, Iván
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
title Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
title_full Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
title_fullStr Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
title_full_unstemmed Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
title_short Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
title_sort carotid plaque assessment reclassifies patients with inflammatory bowel disease into very-high cardiovascular risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069809/
https://www.ncbi.nlm.nih.gov/pubmed/33924727
http://dx.doi.org/10.3390/jcm10081671
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