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Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action

Among the vast variety of plant-derived phytochemicals, the group of carotenoids has continuously been investigated in order to optimize their potential application in the area of dietary intervention and medicine. One organ which has been especially targeted in many of these studies and clinical tr...

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Autores principales: Dulińska-Litewka, Joanna, Sharoni, Yoav, Hałubiec, Przemysław, Łazarczyk, Agnieszka, Szafrański, Oskar, McCubrey, James A., Gąsiorkiewicz, Bartosz, Laidler, Piotr, Bohn, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069951/
https://www.ncbi.nlm.nih.gov/pubmed/33920256
http://dx.doi.org/10.3390/antiox10040585
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author Dulińska-Litewka, Joanna
Sharoni, Yoav
Hałubiec, Przemysław
Łazarczyk, Agnieszka
Szafrański, Oskar
McCubrey, James A.
Gąsiorkiewicz, Bartosz
Laidler, Piotr
Bohn, Torsten
author_facet Dulińska-Litewka, Joanna
Sharoni, Yoav
Hałubiec, Przemysław
Łazarczyk, Agnieszka
Szafrański, Oskar
McCubrey, James A.
Gąsiorkiewicz, Bartosz
Laidler, Piotr
Bohn, Torsten
author_sort Dulińska-Litewka, Joanna
collection PubMed
description Among the vast variety of plant-derived phytochemicals, the group of carotenoids has continuously been investigated in order to optimize their potential application in the area of dietary intervention and medicine. One organ which has been especially targeted in many of these studies and clinical trials is the human prostate. Without doubt, carotenoids (and their endogenous derivatives—retinoids and other apo-carotenoids) are involved in intra- and intercellular signaling, cell growth and differentiation of prostate tissue. Due to the accumulation of new data on the role of different carotenoids such as lycopene (LC) and β-carotene (BC) in prostatic physiology and pathology, the present review aims to cover the past ten years of research in this area. Data from experimental studies are presented in the first part of the review, while epidemiological studies are disclosed and discussed in the second part. The objective of this compilation is to emphasize the present state of knowledge regarding the most potent molecular targets of carotenoids and their main metabolites, as well as to propose promising carotenoid agents for the prevention and treatment of prostatic diseases.
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spelling pubmed-80699512021-04-26 Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action Dulińska-Litewka, Joanna Sharoni, Yoav Hałubiec, Przemysław Łazarczyk, Agnieszka Szafrański, Oskar McCubrey, James A. Gąsiorkiewicz, Bartosz Laidler, Piotr Bohn, Torsten Antioxidants (Basel) Review Among the vast variety of plant-derived phytochemicals, the group of carotenoids has continuously been investigated in order to optimize their potential application in the area of dietary intervention and medicine. One organ which has been especially targeted in many of these studies and clinical trials is the human prostate. Without doubt, carotenoids (and their endogenous derivatives—retinoids and other apo-carotenoids) are involved in intra- and intercellular signaling, cell growth and differentiation of prostate tissue. Due to the accumulation of new data on the role of different carotenoids such as lycopene (LC) and β-carotene (BC) in prostatic physiology and pathology, the present review aims to cover the past ten years of research in this area. Data from experimental studies are presented in the first part of the review, while epidemiological studies are disclosed and discussed in the second part. The objective of this compilation is to emphasize the present state of knowledge regarding the most potent molecular targets of carotenoids and their main metabolites, as well as to propose promising carotenoid agents for the prevention and treatment of prostatic diseases. MDPI 2021-04-10 /pmc/articles/PMC8069951/ /pubmed/33920256 http://dx.doi.org/10.3390/antiox10040585 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dulińska-Litewka, Joanna
Sharoni, Yoav
Hałubiec, Przemysław
Łazarczyk, Agnieszka
Szafrański, Oskar
McCubrey, James A.
Gąsiorkiewicz, Bartosz
Laidler, Piotr
Bohn, Torsten
Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action
title Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action
title_full Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action
title_fullStr Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action
title_full_unstemmed Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action
title_short Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action
title_sort recent progress in discovering the role of carotenoids and their metabolites in prostatic physiology and pathology with a focus on prostate cancer—a review—part i: molecular mechanisms of carotenoid action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069951/
https://www.ncbi.nlm.nih.gov/pubmed/33920256
http://dx.doi.org/10.3390/antiox10040585
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