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Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities

SIMPLE SUMMARY: Multi-strain probiotics are composed of more than one species or strains of bacteria and sometimes, including some fungal species with benefits to human and animals’ health. The mechanisms by which multi-strain probiotics exert their effects include cell–cell communications, interact...

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Autores principales: Kwoji, Iliya D., Aiyegoro, Olayinka A., Okpeku, Moses, Adeleke, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070017/
https://www.ncbi.nlm.nih.gov/pubmed/33924344
http://dx.doi.org/10.3390/biology10040322
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author Kwoji, Iliya D.
Aiyegoro, Olayinka A.
Okpeku, Moses
Adeleke, Matthew A.
author_facet Kwoji, Iliya D.
Aiyegoro, Olayinka A.
Okpeku, Moses
Adeleke, Matthew A.
author_sort Kwoji, Iliya D.
collection PubMed
description SIMPLE SUMMARY: Multi-strain probiotics are composed of more than one species or strains of bacteria and sometimes, including some fungal species with benefits to human and animals’ health. The mechanisms by which multi-strain probiotics exert their effects include cell–cell communications, interactions with the host tissues, and modulation of the immune systems. Multi-strain probiotics applications include alleviation of disease conditions, inhibition of pathogens, and restoration of the gastrointestinal microbiome. Despite all these benefits, the potential of using multi-strain probiotics is still not fully explored. ABSTRACT: The use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the non-therapeutic use of antibiotics for prophylaxis and growth promotion, especially in animal husbandry. While single-strain probiotics are beneficial to health, multi-strain probiotics might be more helpful because of synergy and additive effects among the individual isolates. This article documents the mechanisms by which multi-strain probiotics exert their effects in managing infectious and non-infectious diseases, inhibiting antibiotic-resistant pathogens and health improvement. The administration of multi-strain probiotics was revealed to effectively alleviate bowel tract conditions, such as irritable bowel syndrome, inhibition of pathogens and modulation of the immune system and gut microbiota. Finally, while most of the current research focuses on comparing the effects of multi-strain and single-strain probiotics, there is a dearth of information on the molecular mechanisms of synergy among multi-strain probiotics isolates. This forms a basis for future research in the development of multi-strain probiotics for enhanced health benefits.
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spelling pubmed-80700172021-04-26 Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities Kwoji, Iliya D. Aiyegoro, Olayinka A. Okpeku, Moses Adeleke, Matthew A. Biology (Basel) Review SIMPLE SUMMARY: Multi-strain probiotics are composed of more than one species or strains of bacteria and sometimes, including some fungal species with benefits to human and animals’ health. The mechanisms by which multi-strain probiotics exert their effects include cell–cell communications, interactions with the host tissues, and modulation of the immune systems. Multi-strain probiotics applications include alleviation of disease conditions, inhibition of pathogens, and restoration of the gastrointestinal microbiome. Despite all these benefits, the potential of using multi-strain probiotics is still not fully explored. ABSTRACT: The use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the non-therapeutic use of antibiotics for prophylaxis and growth promotion, especially in animal husbandry. While single-strain probiotics are beneficial to health, multi-strain probiotics might be more helpful because of synergy and additive effects among the individual isolates. This article documents the mechanisms by which multi-strain probiotics exert their effects in managing infectious and non-infectious diseases, inhibiting antibiotic-resistant pathogens and health improvement. The administration of multi-strain probiotics was revealed to effectively alleviate bowel tract conditions, such as irritable bowel syndrome, inhibition of pathogens and modulation of the immune system and gut microbiota. Finally, while most of the current research focuses on comparing the effects of multi-strain and single-strain probiotics, there is a dearth of information on the molecular mechanisms of synergy among multi-strain probiotics isolates. This forms a basis for future research in the development of multi-strain probiotics for enhanced health benefits. MDPI 2021-04-13 /pmc/articles/PMC8070017/ /pubmed/33924344 http://dx.doi.org/10.3390/biology10040322 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Kwoji, Iliya D.
Aiyegoro, Olayinka A.
Okpeku, Moses
Adeleke, Matthew A.
Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
title Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
title_full Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
title_fullStr Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
title_full_unstemmed Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
title_short Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
title_sort multi-strain probiotics: synergy among isolates enhances biological activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070017/
https://www.ncbi.nlm.nih.gov/pubmed/33924344
http://dx.doi.org/10.3390/biology10040322
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