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Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study

Properly working antioxidant defence systems are important for fetal development. One of the nutrients with antioxidant activity is selenium. Increased maternal selenium intake has been associated with reduced risk for being small for gestational age and preterm delivery. Based on the Norwegian Moth...

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Autores principales: Modzelewska, Dominika, Solé-Navais, Pol, Brantsæter, Anne Lise, Flatley, Christopher, Elfvin, Anders, Meltzer, Helle Margrete, Sengpiel, Verena, Barman, Malin, Jacobsson, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070093/
https://www.ncbi.nlm.nih.gov/pubmed/33918747
http://dx.doi.org/10.3390/nu13041239
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author Modzelewska, Dominika
Solé-Navais, Pol
Brantsæter, Anne Lise
Flatley, Christopher
Elfvin, Anders
Meltzer, Helle Margrete
Sengpiel, Verena
Barman, Malin
Jacobsson, Bo
author_facet Modzelewska, Dominika
Solé-Navais, Pol
Brantsæter, Anne Lise
Flatley, Christopher
Elfvin, Anders
Meltzer, Helle Margrete
Sengpiel, Verena
Barman, Malin
Jacobsson, Bo
author_sort Modzelewska, Dominika
collection PubMed
description Properly working antioxidant defence systems are important for fetal development. One of the nutrients with antioxidant activity is selenium. Increased maternal selenium intake has been associated with reduced risk for being small for gestational age and preterm delivery. Based on the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, we investigated the association of maternal selenium intake from food and dietary supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with neonatal health, measured as two composite variables (neonatal morbidity/mortality and neonatal intervention). Low maternal dietary selenium intake (<30 µg/day) was associated with increased risk for neonatal morbidity/mortality (adjusted odds ratio (adjOR) 1.36, 95% confidence interval (95% CI) 1.08–1.69) and neonatal intervention (adjOR 1.16, 95% CI 1.01–1.34). Using continuous variables, there were no associations between maternal selenium intake (from diet or supplements) or whole-blood selenium concentration and neonatal outcome in the adjusted models. Our findings suggest that sufficient maternal dietary selenium intake is associated with neonatal outcome. Adhering to the dietary recommendations may help ensure an adequate supply of selenium for a healthy pregnancy and optimal fetal development.
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spelling pubmed-80700932021-04-26 Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study Modzelewska, Dominika Solé-Navais, Pol Brantsæter, Anne Lise Flatley, Christopher Elfvin, Anders Meltzer, Helle Margrete Sengpiel, Verena Barman, Malin Jacobsson, Bo Nutrients Article Properly working antioxidant defence systems are important for fetal development. One of the nutrients with antioxidant activity is selenium. Increased maternal selenium intake has been associated with reduced risk for being small for gestational age and preterm delivery. Based on the Norwegian Mother, Father, and Child Cohort Study and the Medical Birth Registry of Norway, we investigated the association of maternal selenium intake from food and dietary supplements during the first half of pregnancy (n = 71,728 women) and selenium status in mid-pregnancy (n = 2628 women) with neonatal health, measured as two composite variables (neonatal morbidity/mortality and neonatal intervention). Low maternal dietary selenium intake (<30 µg/day) was associated with increased risk for neonatal morbidity/mortality (adjusted odds ratio (adjOR) 1.36, 95% confidence interval (95% CI) 1.08–1.69) and neonatal intervention (adjOR 1.16, 95% CI 1.01–1.34). Using continuous variables, there were no associations between maternal selenium intake (from diet or supplements) or whole-blood selenium concentration and neonatal outcome in the adjusted models. Our findings suggest that sufficient maternal dietary selenium intake is associated with neonatal outcome. Adhering to the dietary recommendations may help ensure an adequate supply of selenium for a healthy pregnancy and optimal fetal development. MDPI 2021-04-09 /pmc/articles/PMC8070093/ /pubmed/33918747 http://dx.doi.org/10.3390/nu13041239 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Modzelewska, Dominika
Solé-Navais, Pol
Brantsæter, Anne Lise
Flatley, Christopher
Elfvin, Anders
Meltzer, Helle Margrete
Sengpiel, Verena
Barman, Malin
Jacobsson, Bo
Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study
title Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study
title_full Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study
title_fullStr Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study
title_full_unstemmed Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study
title_short Maternal Dietary Selenium Intake during Pregnancy and Neonatal Outcomes in the Norwegian Mother, Father, and Child Cohort Study
title_sort maternal dietary selenium intake during pregnancy and neonatal outcomes in the norwegian mother, father, and child cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070093/
https://www.ncbi.nlm.nih.gov/pubmed/33918747
http://dx.doi.org/10.3390/nu13041239
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