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Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study
Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients wit...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070109/ https://www.ncbi.nlm.nih.gov/pubmed/33921486 http://dx.doi.org/10.3390/medicina57040374 |
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author | Kikuchi, Masahiro Harada, Hiroyuki Asato, Ryo Hamaguchi, Kiyomi Tamaki, Hisanobu Mizuta, Masanobu Hori, Ryusuke Kojima, Tsuyoshi Honda, Keigo Tsujimura, Takashi Kumabe, Yohei Ichimaru, Kazuyuki Kitani, Yoshiharu Ushiro, Koji Kitamura, Morimasa Shinohara, Shogo Omori, Koichi |
author_facet | Kikuchi, Masahiro Harada, Hiroyuki Asato, Ryo Hamaguchi, Kiyomi Tamaki, Hisanobu Mizuta, Masanobu Hori, Ryusuke Kojima, Tsuyoshi Honda, Keigo Tsujimura, Takashi Kumabe, Yohei Ichimaru, Kazuyuki Kitani, Yoshiharu Ushiro, Koji Kitamura, Morimasa Shinohara, Shogo Omori, Koichi |
author_sort | Kikuchi, Masahiro |
collection | PubMed |
description | Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analysis. Results: LLN metastasis was noted in 67 patients (7.1%). Habitual alcohol consumption and clinical neck node metastasis were independent risk factors for LLN metastasis. LLN metastasis was an independent prognostic factor for disease-free and overall survival, although LLN dissection did not improve survival outcomes. Conclusion: LLN metastasis is an independent adverse prognostic factor. Further prospective studies are needed to fully assess the extent of LLN dissection required in OSCC patients. |
format | Online Article Text |
id | pubmed-8070109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80701092021-04-26 Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study Kikuchi, Masahiro Harada, Hiroyuki Asato, Ryo Hamaguchi, Kiyomi Tamaki, Hisanobu Mizuta, Masanobu Hori, Ryusuke Kojima, Tsuyoshi Honda, Keigo Tsujimura, Takashi Kumabe, Yohei Ichimaru, Kazuyuki Kitani, Yoshiharu Ushiro, Koji Kitamura, Morimasa Shinohara, Shogo Omori, Koichi Medicina (Kaunas) Article Backgrounds and Objectives: The epidemiology and prognostic role of lingual lymph node (LLN) metastasis in patients with oral squamous cell carcinoma (OSCC) remain unclear. Here, we aimed to analyze the clinicopathological features, risk factors, and prognostic role of LLN metastasis in patients with OSCC. Materials and Methods: In total, 945 patients with OSCC were retrospectively analyzed. Clinicopathological features were compared between patients with and without LLN metastasis. The risk factors of LLN metastasis and its effects on survival outcomes were evaluated using multi-variate analysis. Results: LLN metastasis was noted in 67 patients (7.1%). Habitual alcohol consumption and clinical neck node metastasis were independent risk factors for LLN metastasis. LLN metastasis was an independent prognostic factor for disease-free and overall survival, although LLN dissection did not improve survival outcomes. Conclusion: LLN metastasis is an independent adverse prognostic factor. Further prospective studies are needed to fully assess the extent of LLN dissection required in OSCC patients. MDPI 2021-04-12 /pmc/articles/PMC8070109/ /pubmed/33921486 http://dx.doi.org/10.3390/medicina57040374 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kikuchi, Masahiro Harada, Hiroyuki Asato, Ryo Hamaguchi, Kiyomi Tamaki, Hisanobu Mizuta, Masanobu Hori, Ryusuke Kojima, Tsuyoshi Honda, Keigo Tsujimura, Takashi Kumabe, Yohei Ichimaru, Kazuyuki Kitani, Yoshiharu Ushiro, Koji Kitamura, Morimasa Shinohara, Shogo Omori, Koichi Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study |
title | Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study |
title_full | Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study |
title_fullStr | Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study |
title_full_unstemmed | Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study |
title_short | Lingual Lymph Node Metastases as a Prognostic Factor in Oral Squamous Cell Carcinoma—A Retrospective Multicenter Study |
title_sort | lingual lymph node metastases as a prognostic factor in oral squamous cell carcinoma—a retrospective multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070109/ https://www.ncbi.nlm.nih.gov/pubmed/33921486 http://dx.doi.org/10.3390/medicina57040374 |
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