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Serum Adropin Levels in Patients on Hemodialysis

Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyper...

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Autores principales: Boric-Skaro, Dijana, Mizdrak, Maja, Luketin, Mirko, Martinovic, Dinko, Tokic, Daria, Vilovic, Marino, Supe-Domic, Daniela, Kurir, Tina Ticinovic, Bozic, Josko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070137/
https://www.ncbi.nlm.nih.gov/pubmed/33920330
http://dx.doi.org/10.3390/life11040337
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author Boric-Skaro, Dijana
Mizdrak, Maja
Luketin, Mirko
Martinovic, Dinko
Tokic, Daria
Vilovic, Marino
Supe-Domic, Daniela
Kurir, Tina Ticinovic
Bozic, Josko
author_facet Boric-Skaro, Dijana
Mizdrak, Maja
Luketin, Mirko
Martinovic, Dinko
Tokic, Daria
Vilovic, Marino
Supe-Domic, Daniela
Kurir, Tina Ticinovic
Bozic, Josko
author_sort Boric-Skaro, Dijana
collection PubMed
description Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyperlipidemia, chronic low-grade inflammation, and malnutrition the aim of our study was to investigate serum adropin levels in HD patients to evaluate possible associations with nutritional status and other relevant clinical and laboratory parameters. The study included 70 patients on HD and 60 healthy controls. Serum adropin levels were determined by an enzyme-linked immunosorbent assay in a commercially available diagnostic kit. Serum adropin levels were significantly lower in the HD group compared to the control group (2.20 ± 0.72 vs. 4.05 ± 0.93 ng/mL, p < 0.001). Moreover, there was a significant negative correlation with malnutrition-inflammation score (r = −0.476, p < 0.001), dialysis malnutrition score (r = −0.350, p = 0.003), HD duration (r = −0.305, p = 0.010), and high sensitivity C-reactive protein (hsCRP) (r = −0.646, p < 0.001). Additionally, there was a significant negative correlation between adropin levels and pre-dialysis systolic (r = −0.301, p = 0.011) and diastolic blood pressure (r = −0.299, p = 0.011). These results are implying that adropin is potentially involved in the pathophysiological mechanisms of chronic kidney disease (CKD)/HD and its complications. However, future larger scale longitudinal studies need to further address it.
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spelling pubmed-80701372021-04-26 Serum Adropin Levels in Patients on Hemodialysis Boric-Skaro, Dijana Mizdrak, Maja Luketin, Mirko Martinovic, Dinko Tokic, Daria Vilovic, Marino Supe-Domic, Daniela Kurir, Tina Ticinovic Bozic, Josko Life (Basel) Article Adropin is a novel pleotropic peptide involved in energy homeostasis, with possible contribution to cardiovascular protection through production of nitric oxide and subsequent blood pressure regulation. Given that patients undergoing hemodialysis (HD) are related with high cardiovascular risk, hyperlipidemia, chronic low-grade inflammation, and malnutrition the aim of our study was to investigate serum adropin levels in HD patients to evaluate possible associations with nutritional status and other relevant clinical and laboratory parameters. The study included 70 patients on HD and 60 healthy controls. Serum adropin levels were determined by an enzyme-linked immunosorbent assay in a commercially available diagnostic kit. Serum adropin levels were significantly lower in the HD group compared to the control group (2.20 ± 0.72 vs. 4.05 ± 0.93 ng/mL, p < 0.001). Moreover, there was a significant negative correlation with malnutrition-inflammation score (r = −0.476, p < 0.001), dialysis malnutrition score (r = −0.350, p = 0.003), HD duration (r = −0.305, p = 0.010), and high sensitivity C-reactive protein (hsCRP) (r = −0.646, p < 0.001). Additionally, there was a significant negative correlation between adropin levels and pre-dialysis systolic (r = −0.301, p = 0.011) and diastolic blood pressure (r = −0.299, p = 0.011). These results are implying that adropin is potentially involved in the pathophysiological mechanisms of chronic kidney disease (CKD)/HD and its complications. However, future larger scale longitudinal studies need to further address it. MDPI 2021-04-11 /pmc/articles/PMC8070137/ /pubmed/33920330 http://dx.doi.org/10.3390/life11040337 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boric-Skaro, Dijana
Mizdrak, Maja
Luketin, Mirko
Martinovic, Dinko
Tokic, Daria
Vilovic, Marino
Supe-Domic, Daniela
Kurir, Tina Ticinovic
Bozic, Josko
Serum Adropin Levels in Patients on Hemodialysis
title Serum Adropin Levels in Patients on Hemodialysis
title_full Serum Adropin Levels in Patients on Hemodialysis
title_fullStr Serum Adropin Levels in Patients on Hemodialysis
title_full_unstemmed Serum Adropin Levels in Patients on Hemodialysis
title_short Serum Adropin Levels in Patients on Hemodialysis
title_sort serum adropin levels in patients on hemodialysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070137/
https://www.ncbi.nlm.nih.gov/pubmed/33920330
http://dx.doi.org/10.3390/life11040337
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