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Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality

Background: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aime...

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Autores principales: Barrett, Helen L., Dekker Nitert, Marloes, D’Emden, Michael, Lingwood, Barbara, de Jersey, Susan, McIntyre, H. David, Callaway, Leonie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070156/
https://www.ncbi.nlm.nih.gov/pubmed/33924317
http://dx.doi.org/10.3390/nu13041266
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author Barrett, Helen L.
Dekker Nitert, Marloes
D’Emden, Michael
Lingwood, Barbara
de Jersey, Susan
McIntyre, H. David
Callaway, Leonie K.
author_facet Barrett, Helen L.
Dekker Nitert, Marloes
D’Emden, Michael
Lingwood, Barbara
de Jersey, Susan
McIntyre, H. David
Callaway, Leonie K.
author_sort Barrett, Helen L.
collection PubMed
description Background: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aimed to examine the utility of monitoring capillary triglycerides in women in late pregnancy. Methods: Twenty-nine women (22 with gestational diabetes (GDM) and 7 without) measured capillary glucose and triglycerides using standard meters at home for four days. On two of those days, they consumed one of two standard isocaloric breakfast meals: a high-fat/low-carbohydrate meal (66% fat) or low fat/high carbohydrate meal (10% fat). Following the standard meals, glucose and triglyceride levels were monitored. Results: Median capillary triglycerides were highly variable between women but did not differ between GDM and normoglycaemic women. There was variability in capillary triglycerides over four days of home monitoring and a difference in incremental area under the curve for capillary triglycerides and glucose between the two standard meals. The high-fat standard meal lowered the incremental area under the curve for capillary glucose (p < 0.0001). Fasting (rho 0.66, p = 0.0002) and postpradial capillary triglycerides measured at home correlated with venous triglyceride levels. Conclusions: The lack of differences in response to dietary fat intake and the correlation between capillary and venous triglycerides suggest that monitoring of capillary triglycerides before and after meals in pregnancy is unlikely to be useful in the routine clinical practice management of women with gestational diabetes mellitus.
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spelling pubmed-80701562021-04-26 Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality Barrett, Helen L. Dekker Nitert, Marloes D’Emden, Michael Lingwood, Barbara de Jersey, Susan McIntyre, H. David Callaway, Leonie K. Nutrients Article Background: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aimed to examine the utility of monitoring capillary triglycerides in women in late pregnancy. Methods: Twenty-nine women (22 with gestational diabetes (GDM) and 7 without) measured capillary glucose and triglycerides using standard meters at home for four days. On two of those days, they consumed one of two standard isocaloric breakfast meals: a high-fat/low-carbohydrate meal (66% fat) or low fat/high carbohydrate meal (10% fat). Following the standard meals, glucose and triglyceride levels were monitored. Results: Median capillary triglycerides were highly variable between women but did not differ between GDM and normoglycaemic women. There was variability in capillary triglycerides over four days of home monitoring and a difference in incremental area under the curve for capillary triglycerides and glucose between the two standard meals. The high-fat standard meal lowered the incremental area under the curve for capillary glucose (p < 0.0001). Fasting (rho 0.66, p = 0.0002) and postpradial capillary triglycerides measured at home correlated with venous triglyceride levels. Conclusions: The lack of differences in response to dietary fat intake and the correlation between capillary and venous triglycerides suggest that monitoring of capillary triglycerides before and after meals in pregnancy is unlikely to be useful in the routine clinical practice management of women with gestational diabetes mellitus. MDPI 2021-04-13 /pmc/articles/PMC8070156/ /pubmed/33924317 http://dx.doi.org/10.3390/nu13041266 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barrett, Helen L.
Dekker Nitert, Marloes
D’Emden, Michael
Lingwood, Barbara
de Jersey, Susan
McIntyre, H. David
Callaway, Leonie K.
Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
title Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
title_full Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
title_fullStr Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
title_full_unstemmed Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
title_short Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
title_sort capillary triglycerides in late pregnancy—challenging to measure, hard to interpret: a cohort study of practicality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070156/
https://www.ncbi.nlm.nih.gov/pubmed/33924317
http://dx.doi.org/10.3390/nu13041266
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