Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini

Local basement membrane (BM) disruption marks the initial step of breast cancer invasion. The activation mechanisms of force-driven BM-weakening remain elusive. We studied the mechanical response of MCF10A-derived human breast cell acini with BMs of tuneable maturation to physical and soluble tumour...

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Detalles Bibliográficos
Autores principales: Gaiko-Shcherbak, Aljona, Eschenbruch, Julian, Kronenberg, Nils M., Teske, Michael, Wolters, Benjamin, Springer, Ronald, Gather, Malte C., Merkel, Rudolf, Hoffmann, Bernd, Noetzel, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070162/
https://www.ncbi.nlm.nih.gov/pubmed/33921304
http://dx.doi.org/10.3390/ijms22083962

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