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Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study

(1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 wee...

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Autores principales: Boscarino, Giovanni, Conti, Maria Giulia, De Luca, Francesca, Di Chiara, Maria, Deli, Giorgia, Bianchi, Marco, Favata, Paola, Cardilli, Viviana, Di Nardo, Giovanni, Parisi, Pasquale, Terrin, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070203/
https://www.ncbi.nlm.nih.gov/pubmed/33918860
http://dx.doi.org/10.3390/nu13041243
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author Boscarino, Giovanni
Conti, Maria Giulia
De Luca, Francesca
Di Chiara, Maria
Deli, Giorgia
Bianchi, Marco
Favata, Paola
Cardilli, Viviana
Di Nardo, Giovanni
Parisi, Pasquale
Terrin, Gianluca
author_facet Boscarino, Giovanni
Conti, Maria Giulia
De Luca, Francesca
Di Chiara, Maria
Deli, Giorgia
Bianchi, Marco
Favata, Paola
Cardilli, Viviana
Di Nardo, Giovanni
Parisi, Pasquale
Terrin, Gianluca
author_sort Boscarino, Giovanni
collection PubMed
description (1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 weeks or birth weight <1500 g, over a 3-year period. They were divided into cases and controls; cases were defined by the detection of HiTG defined as serum triglycerides (TG) value >150 mg/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p < 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4–10 days vs. 4 days, 95% CI 1–7 days, p < 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age ≤28 + 6/7 weeks or birth weight ≤1000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome.
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spelling pubmed-80702032021-04-26 Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study Boscarino, Giovanni Conti, Maria Giulia De Luca, Francesca Di Chiara, Maria Deli, Giorgia Bianchi, Marco Favata, Paola Cardilli, Viviana Di Nardo, Giovanni Parisi, Pasquale Terrin, Gianluca Nutrients Article (1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 weeks or birth weight <1500 g, over a 3-year period. They were divided into cases and controls; cases were defined by the detection of HiTG defined as serum triglycerides (TG) value >150 mg/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p < 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4–10 days vs. 4 days, 95% CI 1–7 days, p < 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age ≤28 + 6/7 weeks or birth weight ≤1000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome. MDPI 2021-04-09 /pmc/articles/PMC8070203/ /pubmed/33918860 http://dx.doi.org/10.3390/nu13041243 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boscarino, Giovanni
Conti, Maria Giulia
De Luca, Francesca
Di Chiara, Maria
Deli, Giorgia
Bianchi, Marco
Favata, Paola
Cardilli, Viviana
Di Nardo, Giovanni
Parisi, Pasquale
Terrin, Gianluca
Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
title Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
title_full Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
title_fullStr Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
title_full_unstemmed Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
title_short Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
title_sort intravenous lipid emulsions affect respiratory outcome in preterm newborn: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070203/
https://www.ncbi.nlm.nih.gov/pubmed/33918860
http://dx.doi.org/10.3390/nu13041243
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