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Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study
(1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 wee...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070203/ https://www.ncbi.nlm.nih.gov/pubmed/33918860 http://dx.doi.org/10.3390/nu13041243 |
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author | Boscarino, Giovanni Conti, Maria Giulia De Luca, Francesca Di Chiara, Maria Deli, Giorgia Bianchi, Marco Favata, Paola Cardilli, Viviana Di Nardo, Giovanni Parisi, Pasquale Terrin, Gianluca |
author_facet | Boscarino, Giovanni Conti, Maria Giulia De Luca, Francesca Di Chiara, Maria Deli, Giorgia Bianchi, Marco Favata, Paola Cardilli, Viviana Di Nardo, Giovanni Parisi, Pasquale Terrin, Gianluca |
author_sort | Boscarino, Giovanni |
collection | PubMed |
description | (1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 weeks or birth weight <1500 g, over a 3-year period. They were divided into cases and controls; cases were defined by the detection of HiTG defined as serum triglycerides (TG) value >150 mg/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p < 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4–10 days vs. 4 days, 95% CI 1–7 days, p < 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age ≤28 + 6/7 weeks or birth weight ≤1000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome. |
format | Online Article Text |
id | pubmed-8070203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80702032021-04-26 Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study Boscarino, Giovanni Conti, Maria Giulia De Luca, Francesca Di Chiara, Maria Deli, Giorgia Bianchi, Marco Favata, Paola Cardilli, Viviana Di Nardo, Giovanni Parisi, Pasquale Terrin, Gianluca Nutrients Article (1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age <32 weeks or birth weight <1500 g, over a 3-year period. They were divided into cases and controls; cases were defined by the detection of HiTG defined as serum triglycerides (TG) value >150 mg/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p < 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4–10 days vs. 4 days, 95% CI 1–7 days, p < 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age ≤28 + 6/7 weeks or birth weight ≤1000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome. MDPI 2021-04-09 /pmc/articles/PMC8070203/ /pubmed/33918860 http://dx.doi.org/10.3390/nu13041243 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boscarino, Giovanni Conti, Maria Giulia De Luca, Francesca Di Chiara, Maria Deli, Giorgia Bianchi, Marco Favata, Paola Cardilli, Viviana Di Nardo, Giovanni Parisi, Pasquale Terrin, Gianluca Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study |
title | Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study |
title_full | Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study |
title_fullStr | Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study |
title_full_unstemmed | Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study |
title_short | Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study |
title_sort | intravenous lipid emulsions affect respiratory outcome in preterm newborn: a case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070203/ https://www.ncbi.nlm.nih.gov/pubmed/33918860 http://dx.doi.org/10.3390/nu13041243 |
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