Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an (18)F-Labeled Analogue of the MDM2 Inhibitor SP-141

Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing (18)F-labeled compounds based on the small molecule inhibitor SP-141 for imaging tumor MDM2 expression levels with p...

Descripción completa

Detalles Bibliográficos
Autores principales: Chitneni, Satish K., Zhou, Zhengyuan, Watts, Brian E., Zalutsky, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070256/
https://www.ncbi.nlm.nih.gov/pubmed/33924734
http://dx.doi.org/10.3390/ph14040358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070256/
https://www.ncbi.nlm.nih.gov/pubmed/33924734
http://dx.doi.org/10.3390/ph14040358

Ejemplares similares