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Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an (18)F-Labeled Analogue of the MDM2 Inhibitor SP-141

Murine double minute 2 (MDM2), a negative regulator of the p53 tumor suppressor protein, is overexpressed in several human cancers. Herein we investigate the feasibility of developing (18)F-labeled compounds based on the small molecule inhibitor SP-141 for imaging tumor MDM2 expression levels with p...

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Detalles Bibliográficos
Autores principales:	Chitneni, Satish K., Zhou, Zhengyuan, Watts, Brian E., Zalutsky, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070256/ https://www.ncbi.nlm.nih.gov/pubmed/33924734 http://dx.doi.org/10.3390/ph14040358

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