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Relationship between CYP3A5 Polymorphism and Tacrolimus Blood Concentration Changes in Allogeneic Hematopoietic Stem Cell Transplant Recipients during Continuous Infusion

A polymorphism in the gene encoding the metabolic enzyme cytochrome P450 family 3 subfamily A member 5 (CYP3A5) is a particularly influential factor in the use of tacrolimus in Japanese patients. Those who are homozygotic for the *3 mutation lack CYP3A5 activity, which results in substantial individ...

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Detalles Bibliográficos
Autores principales:	Yoshikawa, Naoki, Takeshima, Hidemi, Sekine, Masaaki, Akizuki, Keiichi, Hidaka, Tomonori, Shimoda, Kazuya, Ikeda, Ryuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070336/ https://www.ncbi.nlm.nih.gov/pubmed/33920149 http://dx.doi.org/10.3390/ph14040353

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