Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation

SIMPLE SUMMARY: AMHRII, the anti-Müllerian hormone receptor, is selectively expressed in normal sexual organs in healthy adults but is also re-expressed in ovarian, colorectal and lung cancers. In this context, we developed murlentamab, a humanized glyco-engineered anti-AMHRII monoclonal antibody, c...

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Detalles Bibliográficos
Autores principales: Prat, Mélissa, Salon, Marie, Allain, Thibault, Dubreuil, Olivier, Noël, Grégory, Preisser, Laurence, Jean, Bérangère, Cassard, Lydie, Lemée, Fanny, Tabah-Fish, Isabelle, Pipy, Bernard, Jeannin, Pascale, Prost, Jean-François, Barret, Jean-Marc, Coste, Agnès
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070390/
https://www.ncbi.nlm.nih.gov/pubmed/33924378
http://dx.doi.org/10.3390/cancers13081845

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