Cargando…

Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study

Sialidases, also called neuraminidases, are involved in several human pathologies such as neurodegenerative disorders, cancers, as well as infectious and cardiovascular diseases. Several studies have shown that neuraminidases, such as neuraminidase 1 (NEU-1), may be promising pharmacological targets...

Descripción completa

Detalles Bibliográficos
Autores principales: Albrecht, Camille, Akissi, Zachée Louis Evariste, Yao-Kouassi, Philomène Akoua, Alabdul Magid, Abdulmagid, Maurice, Pascal, Duca, Laurent, Voutquenne-Nazabadioko, Laurence, Bennasroune, Amar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070403/
https://www.ncbi.nlm.nih.gov/pubmed/33920466
http://dx.doi.org/10.3390/biomedicines9040411
_version_ 1783683462005260288
author Albrecht, Camille
Akissi, Zachée Louis Evariste
Yao-Kouassi, Philomène Akoua
Alabdul Magid, Abdulmagid
Maurice, Pascal
Duca, Laurent
Voutquenne-Nazabadioko, Laurence
Bennasroune, Amar
author_facet Albrecht, Camille
Akissi, Zachée Louis Evariste
Yao-Kouassi, Philomène Akoua
Alabdul Magid, Abdulmagid
Maurice, Pascal
Duca, Laurent
Voutquenne-Nazabadioko, Laurence
Bennasroune, Amar
author_sort Albrecht, Camille
collection PubMed
description Sialidases, also called neuraminidases, are involved in several human pathologies such as neurodegenerative disorders, cancers, as well as infectious and cardiovascular diseases. Several studies have shown that neuraminidases, such as neuraminidase 1 (NEU-1), may be promising pharmacological targets. Therefore, the discovery of new selective inhibitors of NEU-1 are necessary to better understand the biological functions of this sialidase. In the present study, we describe the isolation and characterization of nine known compounds from Olyra latifolia L. leaves. This plant, known to have several therapeutic properties, belongs to the family of Poaceae and is found in the neotropics and in tropical Africa and Madagascar. Among the purified compounds, feddeiketone B, 2,3-dihydroxy-1-(4-hydroxy-3,5-diméthoxyphényl)-l-propanone, and syringylglycerol were shown to present structural analogy with DANA, and their effects on membrane NEU-1 sialidase activity were evaluated. Our results show that they possess inhibitory effects against NEU-1-mediated sialidase activity at the plasma membrane. In conclusion, we identified new natural bioactive molecules extracted from Olyra latifolia as inhibitors of human NEU-1 of strong interest to elucidate the biological functions of this sialidase and to target this protein involved in several pathophysiological contexts.
format Online
Article
Text
id pubmed-8070403
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80704032021-04-26 Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study Albrecht, Camille Akissi, Zachée Louis Evariste Yao-Kouassi, Philomène Akoua Alabdul Magid, Abdulmagid Maurice, Pascal Duca, Laurent Voutquenne-Nazabadioko, Laurence Bennasroune, Amar Biomedicines Article Sialidases, also called neuraminidases, are involved in several human pathologies such as neurodegenerative disorders, cancers, as well as infectious and cardiovascular diseases. Several studies have shown that neuraminidases, such as neuraminidase 1 (NEU-1), may be promising pharmacological targets. Therefore, the discovery of new selective inhibitors of NEU-1 are necessary to better understand the biological functions of this sialidase. In the present study, we describe the isolation and characterization of nine known compounds from Olyra latifolia L. leaves. This plant, known to have several therapeutic properties, belongs to the family of Poaceae and is found in the neotropics and in tropical Africa and Madagascar. Among the purified compounds, feddeiketone B, 2,3-dihydroxy-1-(4-hydroxy-3,5-diméthoxyphényl)-l-propanone, and syringylglycerol were shown to present structural analogy with DANA, and their effects on membrane NEU-1 sialidase activity were evaluated. Our results show that they possess inhibitory effects against NEU-1-mediated sialidase activity at the plasma membrane. In conclusion, we identified new natural bioactive molecules extracted from Olyra latifolia as inhibitors of human NEU-1 of strong interest to elucidate the biological functions of this sialidase and to target this protein involved in several pathophysiological contexts. MDPI 2021-04-11 /pmc/articles/PMC8070403/ /pubmed/33920466 http://dx.doi.org/10.3390/biomedicines9040411 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Albrecht, Camille
Akissi, Zachée Louis Evariste
Yao-Kouassi, Philomène Akoua
Alabdul Magid, Abdulmagid
Maurice, Pascal
Duca, Laurent
Voutquenne-Nazabadioko, Laurence
Bennasroune, Amar
Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
title Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
title_full Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
title_fullStr Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
title_full_unstemmed Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
title_short Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study
title_sort identification and evaluation of new potential inhibitors of human neuraminidase 1 extracted from olyra latifolia l.: a preliminary study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070403/
https://www.ncbi.nlm.nih.gov/pubmed/33920466
http://dx.doi.org/10.3390/biomedicines9040411
work_keys_str_mv AT albrechtcamille identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT akissizacheelouisevariste identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT yaokouassiphilomeneakoua identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT alabdulmagidabdulmagid identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT mauricepascal identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT ducalaurent identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT voutquennenazabadiokolaurence identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy
AT bennasrouneamar identificationandevaluationofnewpotentialinhibitorsofhumanneuraminidase1extractedfromolyralatifolialapreliminarystudy