Cargando…

Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species

Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a sui...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez-Turiño, Sandra, Calvo, María, Bedoya, Leonor Cecilia, Zhao, Mingmin, García, Juan Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070427/
https://www.ncbi.nlm.nih.gov/pubmed/33920394
http://dx.doi.org/10.3390/microorganisms9040805
_version_ 1783683467578441728
author Martínez-Turiño, Sandra
Calvo, María
Bedoya, Leonor Cecilia
Zhao, Mingmin
García, Juan Antonio
author_facet Martínez-Turiño, Sandra
Calvo, María
Bedoya, Leonor Cecilia
Zhao, Mingmin
García, Juan Antonio
author_sort Martínez-Turiño, Sandra
collection PubMed
description Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of “bridge hosts” in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus Plum pox virus (PPV), analyzing its differential behaviour in three herbaceous species. Our results showed that two VPg mutations in a Nicotiana clevelandii-adapted virus, emerged during adaptation to the bridge-host Arabidopsis thaliana, drastically prompted partial adaptation to Chenopodium foetidum. Although both changes are expected to facilitate productive interactions with eIF(iso)4E, polymorphims detected in PPV VPg and the three eIF(iso)4E studied, extrapolated to a recent VPg:eIF4E structural model, suggested that two adaptation ways can be operating. Remarkably, we found that VPg mutations driving host-range expansion in two non-related species, not only are not associated with cost trade-off constraints in the original host, but also improve fitness on it.
format Online
Article
Text
id pubmed-8070427
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80704272021-04-26 Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species Martínez-Turiño, Sandra Calvo, María Bedoya, Leonor Cecilia Zhao, Mingmin García, Juan Antonio Microorganisms Article Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of “bridge hosts” in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus Plum pox virus (PPV), analyzing its differential behaviour in three herbaceous species. Our results showed that two VPg mutations in a Nicotiana clevelandii-adapted virus, emerged during adaptation to the bridge-host Arabidopsis thaliana, drastically prompted partial adaptation to Chenopodium foetidum. Although both changes are expected to facilitate productive interactions with eIF(iso)4E, polymorphims detected in PPV VPg and the three eIF(iso)4E studied, extrapolated to a recent VPg:eIF4E structural model, suggested that two adaptation ways can be operating. Remarkably, we found that VPg mutations driving host-range expansion in two non-related species, not only are not associated with cost trade-off constraints in the original host, but also improve fitness on it. MDPI 2021-04-11 /pmc/articles/PMC8070427/ /pubmed/33920394 http://dx.doi.org/10.3390/microorganisms9040805 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez-Turiño, Sandra
Calvo, María
Bedoya, Leonor Cecilia
Zhao, Mingmin
García, Juan Antonio
Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
title Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
title_full Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
title_fullStr Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
title_full_unstemmed Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
title_short Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
title_sort virus host jumping can be boosted by adaptation to a bridge plant species
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070427/
https://www.ncbi.nlm.nih.gov/pubmed/33920394
http://dx.doi.org/10.3390/microorganisms9040805
work_keys_str_mv AT martinezturinosandra virushostjumpingcanbeboostedbyadaptationtoabridgeplantspecies
AT calvomaria virushostjumpingcanbeboostedbyadaptationtoabridgeplantspecies
AT bedoyaleonorcecilia virushostjumpingcanbeboostedbyadaptationtoabridgeplantspecies
AT zhaomingmin virushostjumpingcanbeboostedbyadaptationtoabridgeplantspecies
AT garciajuanantonio virushostjumpingcanbeboostedbyadaptationtoabridgeplantspecies