The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs

Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet. Pharmacokinetic parameters of donepezil and its active metabolite 6-O-desmethyldone...

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Detalles Bibliográficos
Autores principales: Bures, Jan, Tacheci, Ilja, Kvetina, Jaroslav, Radochova, Vera, Prchal, Lukas, Kohoutova, Darina, Valis, Martin, Novak, Martin, Dolezal, Rafael, Kopacova, Marcela, Rejchrt, Stanislav, Sestak, Vit, Knoblochova, Veronika, Peterova, Eva, Zdarova Karasova, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070437/
https://www.ncbi.nlm.nih.gov/pubmed/33918638
http://dx.doi.org/10.3390/molecules26082160

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