Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base

Soluble “SOSIP”-stabilized envelope (Env) trimers are promising HIV-vaccine immunogens. However, they induce high-titer responses against the glycan-free trimer base, which is occluded on native virions. To delineate the effect on base responses of priming with immunogens targeting the fusion peptid...

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Detalles Bibliográficos
Autores principales: Corrigan, Angela R., Duan, Hongying, Cheng, Cheng, Gonelli, Christopher A., Ou, Li, Xu, Kai, DeMouth, Megan E., Geng, Hui, Narpala, Sandeep, O’Connell, Sarah, Zhang, Baoshan, Zhou, Tongqing, Basappa, Manjula, Boyington, Jeffrey C., Chen, Steven J., O’Dell, Sijy, Pegu, Amarendra, Stephens, Tyler, Tsybovsky, Yaroslav, van Schooten, Jelle, Todd, John P., Wang, Shuishu, Doria-Rose, Nicole A., Foulds, Kathryn E., Koup, Richard A., McDermott, Adrian B., van Gils, Marit J., Kwong, Peter D., Mascola, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070658/
https://www.ncbi.nlm.nih.gov/pubmed/33826898
http://dx.doi.org/10.1016/j.celrep.2021.108937

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