Cargando…

Misshapen Disruption Cooperates with Ras(V12) to Drive Tumorigenesis

Although RAS family genes play essential roles in tumorigenesis, effective treatments targeting RAS-related tumors are lacking, partly because of an incomplete understanding of the complex signaling crosstalk within RAS-related tumors. Here, we performed a large-scale genetic screen in Drosophila ey...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Du, Lu, Jin-Yu, Li, Xiaoqin, Zhao, Sihua, Xu, Wenyan, Fang, Jinan, Wang, Xing, Ma, Xianjue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070713/ https://www.ncbi.nlm.nih.gov/pubmed/33919765 http://dx.doi.org/10.3390/cells10040894

Ejemplares similares

Misshapen orders an egg roll
por: Short, Ben
Publicado: (2013)

Misshapen decreases integrin levels to promote epithelial motility and planar polarity in Drosophila
por: Lewellyn, Lindsay, et al.
Publicado: (2013)

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration
por: Plutoni, Cédric, et al.
Publicado: (2019)

Characterization of a Lamellocyte Transcriptional Enhancer Located within the misshapen Gene of Drosophila melanogaster
por: Tokusumi, Tsuyoshi, et al.
Publicado: (2009)

Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
por: Fu, Guotong, et al.
Publicado: (2017)

Cooperative loss of RAS feedback regulation drives myeloid leukemognesis
por: Zhao, Zhen, et al.
Publicado: (2015)

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis
por: Ahmad, I, et al.
Publicado: (2011)

Taurodontism, variations in tooth number, and misshapened crowns in Wnt10a null mice and human kindreds
por: Yang, Jie, et al.
Publicado: (2015)

The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
por: Kiely, Evan, et al.
Publicado: (2021)

Factors targeting MED12 to drive tumorigenesis?
por: Bullerdiek, Jörn, et al.
Publicado: (2018)

A Screen for Round Egg Mutants in Drosophila Identifies Tricornered, Furry, and Misshapen as Regulators of Egg Chamber Elongation
por: Horne-Badovinac, Sally, et al.
Publicado: (2012)

Characterisation of Dichelobacter nodosus on Misshapen and Damaged Ovine Feet: A Longitudinal Study of Four UK Sheep Flocks
por: Best, Caroline M., et al.
Publicado: (2021)

MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes
por: Taylor, E, et al.
Publicado: (2017)

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
por: Chang, Zhe, et al.
Publicado: (2014)

HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
por: Jiang, Qiwei, et al.
Publicado: (2023)

Ras(V12); scrib(−/−) Tumors: A Cooperative Oncogenesis Model Fueled by Tumor/Host Interactions
por: Dillard, Caroline, et al.
Publicado: (2021)

The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12
por: Jia, Shuting, et al.
Publicado: (2012)

YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis
por: Li, Nianshuang, et al.
Publicado: (2023)

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
por: Heidorn, Sonja J., et al.
Publicado: (2010)

Loss of the emei tumor suppressor promotes tumorigenesis via the JNK and Hippo pathway
por: Yang, Shuai, et al.
Publicado: (2022)

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder
por: Ahmad, Imran, et al.
Publicado: (2011)

Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
Publicado: (2019)

Sos-mediated cross activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
por: Jeng, Hao-Hsuan, et al.
Publicado: (2012)

The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy
por: Chittaranjan, Suganthi, et al.
Publicado: (2015)

Modelling Cooperative Tumorigenesis in Drosophila
por: Richardson, Helena E., et al.
Publicado: (2018)

Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
por: Bhargava, Ajay, et al.
Publicado: (2016)

An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene
por: Azman, Muhammad S, et al.
Publicado: (2023)

Molecular genetics and cellular events of K-Ras-driven tumorigenesis
por: Jinesh, G G, et al.
Publicado: (2018)

The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71
por: Leong, Shi Yun, et al.
Publicado: (2015)

Clonal Extinction Drives Tumorigenesis
por: Amaro, Adriana, et al.
Publicado: (2023)

Localized RAS signaling drives cancer
por: Basu, Sandip K., et al.
Publicado: (2019)

The oncoprotein H-Ras(V12 )increases mitochondrial metabolism
por: Telang, Sucheta, et al.
Publicado: (2007)

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket
por: Wallon, Lauren, et al.
Publicado: (2022)

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling
por: Khoo, Peytee, et al.
Publicado: (2013)

A high level of liver-specific expression of oncogenic Kras(V12) drives robust liver tumorigenesis in transgenic zebrafish
por: Nguyen, Anh Tuan, et al.
Publicado: (2011)

Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis
por: Umetani, N, et al.
Publicado: (2000)

Ras Oncogene-Mediated Progressive Silencing of Extracellular Superoxide Dismutase in Tumorigenesis
por: Cammarota, Francesca, et al.
Publicado: (2015)

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression
por: Kortlever, Roderik M., et al.
Publicado: (2017)

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways
por: Janda, Elzbieta, et al.
Publicado: (2002)

Hyperglycemia Promotes K-Ras-Induced Lung Tumorigenesis through BASCs Amplification
por: Micucci, Carla, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0bd8clbc6jsvcd9ioin344fs5s