Cargando…

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over the past decades in parallel to the advancement in medicine, especially in regard to the utilization of foreign body devices. Many new specie...

Descripción completa

Detalles Bibliográficos
Autores principales: Michels, Ricarda, Last, Katharina, Becker, Sören L., Papan, Cihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070739/
https://www.ncbi.nlm.nih.gov/pubmed/33919781
http://dx.doi.org/10.3390/microorganisms9040830
_version_ 1783683540482785280
author Michels, Ricarda
Last, Katharina
Becker, Sören L.
Papan, Cihan
author_facet Michels, Ricarda
Last, Katharina
Becker, Sören L.
Papan, Cihan
author_sort Michels, Ricarda
collection PubMed
description Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over the past decades in parallel to the advancement in medicine, especially in regard to the utilization of foreign body devices. Many new species have been described within the past years, while clinical information to most of those species is still sparse. In addition, interspecies differences that render some species more virulent than others have to be taken into account. The distinct populations in which CoNS infections play a prominent role are preterm neonates, patients with implanted medical devices, immunodeficient patients, and those with other relevant comorbidities. Due to the property of CoNS to colonize the human skin, contamination of blood cultures or other samples occurs frequently. Hence, the main diagnostic hurdle is to correctly identify the cases in which CoNS are causative agents rather than contaminants. However, neither phenotypic nor genetic tools have been able to provide a satisfying solution to this problem. Another dilemma of CoNS in clinical practice pertains to their extensive antimicrobial resistance profile, especially in healthcare settings. Therefore, true infections caused by CoNS most often necessitate the use of second-line antimicrobial drugs.
format Online
Article
Text
id pubmed-8070739
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80707392021-04-26 Update on Coagulase-Negative Staphylococci—What the Clinician Should Know Michels, Ricarda Last, Katharina Becker, Sören L. Papan, Cihan Microorganisms Review Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over the past decades in parallel to the advancement in medicine, especially in regard to the utilization of foreign body devices. Many new species have been described within the past years, while clinical information to most of those species is still sparse. In addition, interspecies differences that render some species more virulent than others have to be taken into account. The distinct populations in which CoNS infections play a prominent role are preterm neonates, patients with implanted medical devices, immunodeficient patients, and those with other relevant comorbidities. Due to the property of CoNS to colonize the human skin, contamination of blood cultures or other samples occurs frequently. Hence, the main diagnostic hurdle is to correctly identify the cases in which CoNS are causative agents rather than contaminants. However, neither phenotypic nor genetic tools have been able to provide a satisfying solution to this problem. Another dilemma of CoNS in clinical practice pertains to their extensive antimicrobial resistance profile, especially in healthcare settings. Therefore, true infections caused by CoNS most often necessitate the use of second-line antimicrobial drugs. MDPI 2021-04-14 /pmc/articles/PMC8070739/ /pubmed/33919781 http://dx.doi.org/10.3390/microorganisms9040830 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michels, Ricarda
Last, Katharina
Becker, Sören L.
Papan, Cihan
Update on Coagulase-Negative Staphylococci—What the Clinician Should Know
title Update on Coagulase-Negative Staphylococci—What the Clinician Should Know
title_full Update on Coagulase-Negative Staphylococci—What the Clinician Should Know
title_fullStr Update on Coagulase-Negative Staphylococci—What the Clinician Should Know
title_full_unstemmed Update on Coagulase-Negative Staphylococci—What the Clinician Should Know
title_short Update on Coagulase-Negative Staphylococci—What the Clinician Should Know
title_sort update on coagulase-negative staphylococci—what the clinician should know
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070739/
https://www.ncbi.nlm.nih.gov/pubmed/33919781
http://dx.doi.org/10.3390/microorganisms9040830
work_keys_str_mv AT michelsricarda updateoncoagulasenegativestaphylococciwhattheclinicianshouldknow
AT lastkatharina updateoncoagulasenegativestaphylococciwhattheclinicianshouldknow
AT beckersorenl updateoncoagulasenegativestaphylococciwhattheclinicianshouldknow
AT papancihan updateoncoagulasenegativestaphylococciwhattheclinicianshouldknow