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Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070827/ https://www.ncbi.nlm.nih.gov/pubmed/33919820 http://dx.doi.org/10.3390/polym13081272 |
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author | Visan, Anita Ioana Popescu-Pelin, Gianina Socol, Gabriel |
author_facet | Visan, Anita Ioana Popescu-Pelin, Gianina Socol, Gabriel |
author_sort | Visan, Anita Ioana |
collection | PubMed |
description | The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery. |
format | Online Article Text |
id | pubmed-8070827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80708272021-04-26 Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review Visan, Anita Ioana Popescu-Pelin, Gianina Socol, Gabriel Polymers (Basel) Review The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery. MDPI 2021-04-14 /pmc/articles/PMC8070827/ /pubmed/33919820 http://dx.doi.org/10.3390/polym13081272 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Visan, Anita Ioana Popescu-Pelin, Gianina Socol, Gabriel Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review |
title | Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review |
title_full | Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review |
title_fullStr | Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review |
title_full_unstemmed | Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review |
title_short | Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review |
title_sort | degradation behavior of polymers used as coating materials for drug delivery—a basic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070827/ https://www.ncbi.nlm.nih.gov/pubmed/33919820 http://dx.doi.org/10.3390/polym13081272 |
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