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Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery...

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Autores principales: Visan, Anita Ioana, Popescu-Pelin, Gianina, Socol, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070827/
https://www.ncbi.nlm.nih.gov/pubmed/33919820
http://dx.doi.org/10.3390/polym13081272
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author Visan, Anita Ioana
Popescu-Pelin, Gianina
Socol, Gabriel
author_facet Visan, Anita Ioana
Popescu-Pelin, Gianina
Socol, Gabriel
author_sort Visan, Anita Ioana
collection PubMed
description The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.
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spelling pubmed-80708272021-04-26 Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review Visan, Anita Ioana Popescu-Pelin, Gianina Socol, Gabriel Polymers (Basel) Review The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery. MDPI 2021-04-14 /pmc/articles/PMC8070827/ /pubmed/33919820 http://dx.doi.org/10.3390/polym13081272 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Visan, Anita Ioana
Popescu-Pelin, Gianina
Socol, Gabriel
Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
title Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
title_full Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
title_fullStr Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
title_full_unstemmed Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
title_short Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review
title_sort degradation behavior of polymers used as coating materials for drug delivery—a basic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070827/
https://www.ncbi.nlm.nih.gov/pubmed/33919820
http://dx.doi.org/10.3390/polym13081272
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