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Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied...

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Autores principales: Liu Chung Ming, Clara, Sesperez, Kimberly, Ben-Sefer, Eitan, Arpon, David, McGrath, Kristine, McClements, Lana, Gentile, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070848/
https://www.ncbi.nlm.nih.gov/pubmed/33919808
http://dx.doi.org/10.3390/cells10040899
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author Liu Chung Ming, Clara
Sesperez, Kimberly
Ben-Sefer, Eitan
Arpon, David
McGrath, Kristine
McClements, Lana
Gentile, Carmine
author_facet Liu Chung Ming, Clara
Sesperez, Kimberly
Ben-Sefer, Eitan
Arpon, David
McGrath, Kristine
McClements, Lana
Gentile, Carmine
author_sort Liu Chung Ming, Clara
collection PubMed
description Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.
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spelling pubmed-80708482021-04-26 Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease Liu Chung Ming, Clara Sesperez, Kimberly Ben-Sefer, Eitan Arpon, David McGrath, Kristine McClements, Lana Gentile, Carmine Cells Review Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article. MDPI 2021-04-14 /pmc/articles/PMC8070848/ /pubmed/33919808 http://dx.doi.org/10.3390/cells10040899 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu Chung Ming, Clara
Sesperez, Kimberly
Ben-Sefer, Eitan
Arpon, David
McGrath, Kristine
McClements, Lana
Gentile, Carmine
Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
title Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
title_full Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
title_fullStr Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
title_full_unstemmed Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
title_short Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
title_sort considerations to model heart disease in women with preeclampsia and cardiovascular disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070848/
https://www.ncbi.nlm.nih.gov/pubmed/33919808
http://dx.doi.org/10.3390/cells10040899
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