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High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks

OBJECTIVE: Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. METHODS AND ANALYSIS: Infants with completed ROP screening, born at <24 GA...

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Autores principales: Lundgren, Pia, Jacobson, Lena, Hård, Anna-Lena, Al-Hawasi, Abbas, Larsson, Eva, Gränse, Lotta, Saric, Marie, Sunnqvist, Birgitta, Tornqvist, Kristina, Wallin, Agneta, Holmstrom, Gerd E, Smith, Lois LE, Morsing, Eva, Hellström, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070879/
https://www.ncbi.nlm.nih.gov/pubmed/33981857
http://dx.doi.org/10.1136/bmjophth-2020-000695
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author Lundgren, Pia
Jacobson, Lena
Hård, Anna-Lena
Al-Hawasi, Abbas
Larsson, Eva
Gränse, Lotta
Saric, Marie
Sunnqvist, Birgitta
Tornqvist, Kristina
Wallin, Agneta
Holmstrom, Gerd E
Smith, Lois LE
Morsing, Eva
Hellström, Ann
author_facet Lundgren, Pia
Jacobson, Lena
Hård, Anna-Lena
Al-Hawasi, Abbas
Larsson, Eva
Gränse, Lotta
Saric, Marie
Sunnqvist, Birgitta
Tornqvist, Kristina
Wallin, Agneta
Holmstrom, Gerd E
Smith, Lois LE
Morsing, Eva
Hellström, Ann
author_sort Lundgren, Pia
collection PubMed
description OBJECTIVE: Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. METHODS AND ANALYSIS: Infants with completed ROP screening, born at <24 GA weeks, 2007–2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. RESULTS: In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9–23.9) and a mean BW of 567 g (range 340–874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment. CONCLUSION: Infants, born at <24 weeks’ GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.
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spelling pubmed-80708792021-05-11 High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks Lundgren, Pia Jacobson, Lena Hård, Anna-Lena Al-Hawasi, Abbas Larsson, Eva Gränse, Lotta Saric, Marie Sunnqvist, Birgitta Tornqvist, Kristina Wallin, Agneta Holmstrom, Gerd E Smith, Lois LE Morsing, Eva Hellström, Ann BMJ Open Ophthalmol Retina OBJECTIVE: Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort. METHODS AND ANALYSIS: Infants with completed ROP screening, born at <24 GA weeks, 2007–2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved. RESULTS: In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9–23.9) and a mean BW of 567 g (range 340–874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment. CONCLUSION: Infants, born at <24 weeks’ GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings. BMJ Publishing Group 2021-04-21 /pmc/articles/PMC8070879/ /pubmed/33981857 http://dx.doi.org/10.1136/bmjophth-2020-000695 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Retina
Lundgren, Pia
Jacobson, Lena
Hård, Anna-Lena
Al-Hawasi, Abbas
Larsson, Eva
Gränse, Lotta
Saric, Marie
Sunnqvist, Birgitta
Tornqvist, Kristina
Wallin, Agneta
Holmstrom, Gerd E
Smith, Lois LE
Morsing, Eva
Hellström, Ann
High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
title High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
title_full High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
title_fullStr High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
title_full_unstemmed High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
title_short High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
title_sort high rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070879/
https://www.ncbi.nlm.nih.gov/pubmed/33981857
http://dx.doi.org/10.1136/bmjophth-2020-000695
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