Cargando…

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was r...

Descripción completa

Detalles Bibliográficos
Autores principales: Daescu, Monica, Iota, Miruna, Serbschi, Constantin, Ion, Alina C., Baibarac, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070936/
https://www.ncbi.nlm.nih.gov/pubmed/33919943
http://dx.doi.org/10.3390/ijms22084046
_version_ 1783683584324796416
author Daescu, Monica
Iota, Miruna
Serbschi, Constantin
Ion, Alina C.
Baibarac, Mihaela
author_facet Daescu, Monica
Iota, Miruna
Serbschi, Constantin
Ion, Alina C.
Baibarac, Mihaela
author_sort Daescu, Monica
collection PubMed
description Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was reported. By exposure of the solution of ASA 0.3 M to UV light, a decrease in the PL band intensity was highlighted. This behavior was revealed for ASA in the presence of phosphate buffer (PB) having the pH equal to 6.4, 7, and 8 or by the interaction with NaOH 0.3 M. A different behavior was reported in the case of ASE. In the presence of PB, an increase in the intensity of the PL band of ASE simultaneously with a change of the ratio between the intensities of the bands at 361–364 and 394–397 nm was highlighted. The differences between PL spectra of ASA and ASE have their origin in the presence of salicylic acid (SAL). The interaction of ASE with NaOH induces a shift of the PL band at 405–407 nm. Arguments for the reaction of ASA with NaOH are shown by Raman scattering and FTIR spectroscopy.
format Online
Article
Text
id pubmed-8070936
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80709362021-04-26 The Influence of UV Light on Photodegradation of Acetylsalicylic Acid Daescu, Monica Iota, Miruna Serbschi, Constantin Ion, Alina C. Baibarac, Mihaela Int J Mol Sci Article Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was reported. By exposure of the solution of ASA 0.3 M to UV light, a decrease in the PL band intensity was highlighted. This behavior was revealed for ASA in the presence of phosphate buffer (PB) having the pH equal to 6.4, 7, and 8 or by the interaction with NaOH 0.3 M. A different behavior was reported in the case of ASE. In the presence of PB, an increase in the intensity of the PL band of ASE simultaneously with a change of the ratio between the intensities of the bands at 361–364 and 394–397 nm was highlighted. The differences between PL spectra of ASA and ASE have their origin in the presence of salicylic acid (SAL). The interaction of ASE with NaOH induces a shift of the PL band at 405–407 nm. Arguments for the reaction of ASA with NaOH are shown by Raman scattering and FTIR spectroscopy. MDPI 2021-04-14 /pmc/articles/PMC8070936/ /pubmed/33919943 http://dx.doi.org/10.3390/ijms22084046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Daescu, Monica
Iota, Miruna
Serbschi, Constantin
Ion, Alina C.
Baibarac, Mihaela
The Influence of UV Light on Photodegradation of Acetylsalicylic Acid
title The Influence of UV Light on Photodegradation of Acetylsalicylic Acid
title_full The Influence of UV Light on Photodegradation of Acetylsalicylic Acid
title_fullStr The Influence of UV Light on Photodegradation of Acetylsalicylic Acid
title_full_unstemmed The Influence of UV Light on Photodegradation of Acetylsalicylic Acid
title_short The Influence of UV Light on Photodegradation of Acetylsalicylic Acid
title_sort influence of uv light on photodegradation of acetylsalicylic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8070936/
https://www.ncbi.nlm.nih.gov/pubmed/33919943
http://dx.doi.org/10.3390/ijms22084046
work_keys_str_mv AT daescumonica theinfluenceofuvlightonphotodegradationofacetylsalicylicacid
AT iotamiruna theinfluenceofuvlightonphotodegradationofacetylsalicylicacid
AT serbschiconstantin theinfluenceofuvlightonphotodegradationofacetylsalicylicacid
AT ionalinac theinfluenceofuvlightonphotodegradationofacetylsalicylicacid
AT baibaracmihaela theinfluenceofuvlightonphotodegradationofacetylsalicylicacid
AT daescumonica influenceofuvlightonphotodegradationofacetylsalicylicacid
AT iotamiruna influenceofuvlightonphotodegradationofacetylsalicylicacid
AT serbschiconstantin influenceofuvlightonphotodegradationofacetylsalicylicacid
AT ionalinac influenceofuvlightonphotodegradationofacetylsalicylicacid
AT baibaracmihaela influenceofuvlightonphotodegradationofacetylsalicylicacid