Cargando…

Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways

SIMPLE SUMMARY: In patients with advanced cancer, hypoxic stress shapes NK cells toward tumor-resistant and immunosuppressive phenotypes. Therefore, a strategy to restore NK cell function within hypoxia would be crucial for successful tumor immunotherapy. By manipulating pO(2) exposure to naïve vs....

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Seon Ah, Moon, Yunwon, Shin, Min Hwa, Kim, Tae-Jin, Chae, Sehyun, Yee, Cassian, Hwang, Daehee, Park, Hyunsung, Lee, Kyung-Mi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071270/ https://www.ncbi.nlm.nih.gov/pubmed/33920906 http://dx.doi.org/10.3390/cancers13081904

Ejemplares similares

Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
por: Moon, Yunwon, et al.
Publicado: (2022)

Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia
por: Lee, Seongyeol, et al.
Publicado: (2017)

Hypoxic repression of CYP7A1 through a HIF-1α- and SHP-independent mechanism
por: Moon, Yunwon, et al.
Publicado: (2016)

HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
por: Moon, Yunwon, et al.
Publicado: (2020)

Chronic LCMV infection regulates the effector T cell response by inducing the generation of less immunogenic dendritic cells
por: Yoo, Seungbo, et al.
Publicado: (2023)

Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways
por: Teng, Rui, et al.
Publicado: (2020)

STAT3 governs the HIF-1α response in IL-15 primed human NK cells
por: Coulibaly, Anna, et al.
Publicado: (2021)

Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity
por: Liu, Yu-Hao, et al.
Publicado: (2021)

NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
por: Vacca, Paola, et al.
Publicado: (2013)

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity
por: Kamerkar, Sushrut, et al.
Publicado: (2022)

Corrigendum to “Hypoxia Impairs NK Cell Cytotoxicity through SHP-1-Mediated Attenuation of STAT3 and ERK Signaling Pathways”
por: Teng, Rui, et al.
Publicado: (2021)

The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation
por: Macedo, Amanda B., et al.
Publicado: (2022)

Homotypic NK cell-to-cell communication controls cytokine responsiveness of innate immune NK cells
por: Kim, Tae-Jin, et al.
Publicado: (2014)

Hypoxia Downregulates MAPK/ERK but Not STAT3 Signaling in ROS-Dependent and HIF-1-Independent Manners in Mouse Embryonic Stem Cells
por: Kučera, Jan, et al.
Publicado: (2017)

Harnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity
por: Min, Bokyung, et al.
Publicado: (2021)

Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
por: Yang, Jian, et al.
Publicado: (2010)

ExoCAS-2: Rapid and Pure Isolation of Exosomes by Anionic Exchange Using Magnetic Beads
por: Kim, Hyunsung, et al.
Publicado: (2021)

Attenuating MKRN1 E3 ligase-mediated AMPKα suppression increases tolerance against metabolic stresses in mice
por: Han, Hyunji, et al.
Publicado: (2018)

The Tetraspanin CD53 Modulates Responses from Activating NK Cell Receptors, Promoting LFA-1 Activation and Dampening NK Cell Effector Functions
por: Todros-Dawda, Izabela, et al.
Publicado: (2014)

The Pathologic and Genetic Characteristics of Extranodal NK/T-Cell Lymphoma
por: Kim, Hyunsung, et al.
Publicado: (2022)

Chenodeoxycholic Acid Reduces Hypoxia Inducible Factor-1α Protein and Its Target Genes
por: Moon, Yunwon, et al.
Publicado: (2015)

Complex role of HIF in cancer: the known, the unknown, and the unexpected
por: Tiburcio, Patricia Denise, et al.
Publicado: (2014)

Transcriptional activation of HIF-1 by a ROS-ERK axis underlies the resistance to photodynamic therapy
por: Lamberti, María Julia, et al.
Publicado: (2017)

CD56(neg)CD16(+) NK cells are activated mature NK cells with impaired effector function during HIV-1 infection
por: Milush, Jeffrey M, et al.
Publicado: (2013)

STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity
por: Meissl, Katrin, et al.
Publicado: (2020)

Novel Dioxygenases, HIF-α Specific Prolyl-hydroxylase and Asparanginyl-hydroxylase: O(2) Switch for Cell Survival
por: Park, Hyunsung
Publicado: (2008)

Lineage Reprogramming of Effector Regulatory T Cells in Cancer
por: Dixon, Michael L., et al.
Publicado: (2021)

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity
por: Pereira, Leticia, et al.
Publicado: (2015)

Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions
por: Roy, Sumedha, et al.
Publicado: (2023)

Epigenetic regulation of NK cell differentiation and effector functions
por: Cichocki, Frank, et al.
Publicado: (2013)

Human NK cells: From development to effector functions
por: Perera Molligoda Arachchige, Arosh Shavinda
Publicado: (2021)

Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity
por: Szűcs, Zsolt, et al.
Publicado: (2020)

IFN‐γ–STAT1‐mediated NK2R expression is involved in the induction of antitumor effector CD8 (+) T cells in vivo
por: Shen, Weidong, et al.
Publicado: (2023)

HIF1α Regulates Early Metabolic Changes due to Activation of Innate Immunity in Nuclear Reprogramming
por: Liu, Chun, et al.
Publicado: (2020)

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells
por: Elsner, Leslie, et al.
Publicado: (2010)

Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27
por: Zwirner, Norberto Walter, et al.
Publicado: (2017)

The ERK and JNK pathways in the regulation of metabolic reprogramming
por: Papa, Salvatore, et al.
Publicado: (2018)

Icaritin Shows Potent Anti-Leukemia Activity on Chronic Myeloid Leukemia In Vitro and In Vivo by Regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT Signalings
por: Zhu, Jian feng, et al.
Publicado: (2011)

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
por: Liu, Ling-Zhi, et al.
Publicado: (2011)

STATs in NK-Cells: The Good, the Bad, and the Ugly
por: Gotthardt, Dagmar, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_lhabrrggsm250urgqirhn5ls01