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IDO1-Targeted Therapy Does Not Control Disease Development in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia

SIMPLE SUMMARY: The tryptophan-catabolizing enzyme IDO1 and its metabolite kynurenine were shown to be enhanced in patients with chronic lymphocytic leukemia (CLL), and their involvement in T cell suppression and immune escape was suggested. As we have observed increased IDO1 expression and kynureni...

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Detalles Bibliográficos
Autores principales:	Öztürk, Selcen, Kalter, Verena, Roessner, Philipp M., Sunbul, Murat, Seiffert, Martina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071295/ https://www.ncbi.nlm.nih.gov/pubmed/33920868 http://dx.doi.org/10.3390/cancers13081899

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