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Sigma-1 Receptor (S1R) Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in Neurodegenerative Diseases

The sigma-1 receptor (S1R) is a 223 amino acid-long transmembrane endoplasmic reticulum (ER) protein. The S1R modulates the activity of multiple effector proteins, but its signaling functions are poorly understood. S1R is associated with cholesterol, and in our recent studies we demonstrated that S1...

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Detalles Bibliográficos
Autores principales:	Zhemkov, Vladimir, Geva, Michal, Hayden, Michael R., Bezprozvanny, Ilya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071319/ https://www.ncbi.nlm.nih.gov/pubmed/33920913 http://dx.doi.org/10.3390/ijms22084082

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