The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results in cardiac contractile dysfunction in cultured H9C2 ca...

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Detalles Bibliográficos
Autores principales: Wüst, Rob C. I., Coolen, Bram F., Held, Ntsiki M., Daal, Mariah R. R., Alizadeh Tazehkandi, Vida, Baks-te Bulte, Luciënne, Wiersma, Marit, Kuster, Diederik W. D., Brundel, Bianca J. J. M., van Weeghel, Michel, Strijkers, Gustav J., Houtkooper, Riekelt H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071362/
https://www.ncbi.nlm.nih.gov/pubmed/33921053
http://dx.doi.org/10.3390/ijms22084100

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