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Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far?
Feline morbillivirus (FeMV) was identified for the first time in stray cats in 2012 in Hong Kong and, since its discovery, it was reported in domestic cats worldwide. Although a potential association between FeMV infection and tubulointerstitial nephritis (TIN) has been suggested, this has not been...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071394/ https://www.ncbi.nlm.nih.gov/pubmed/33921104 http://dx.doi.org/10.3390/v13040683 |
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author | De Luca, Eliana Sautto, Giuseppe Andrea Crisi, Paolo Emidio Lorusso, Alessio |
author_facet | De Luca, Eliana Sautto, Giuseppe Andrea Crisi, Paolo Emidio Lorusso, Alessio |
author_sort | De Luca, Eliana |
collection | PubMed |
description | Feline morbillivirus (FeMV) was identified for the first time in stray cats in 2012 in Hong Kong and, since its discovery, it was reported in domestic cats worldwide. Although a potential association between FeMV infection and tubulointerstitial nephritis (TIN) has been suggested, this has not been proven, and the subject remains controversial. TIN is the most frequent histopathological finding in the context of feline chronic kidney disease (CKD), which is one of the major clinical pathologies in feline medicine. FeMV research has mainly focused on defining the epidemiology, the role of FeMV in the development of CKD, and its in vitro tropism, but the pathogenicity of FeMV is still not clear, partly due to its distinctive biological characteristics, as well as to a lack of a cell culture system for its rapid isolation. In this review, we summarize the current knowledge of FeMV infection, including genetic diversity of FeMV strains, epidemiology, pathogenicity, and clinicopathological findings observed in naturally infected cats. |
format | Online Article Text |
id | pubmed-8071394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80713942021-04-26 Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? De Luca, Eliana Sautto, Giuseppe Andrea Crisi, Paolo Emidio Lorusso, Alessio Viruses Review Feline morbillivirus (FeMV) was identified for the first time in stray cats in 2012 in Hong Kong and, since its discovery, it was reported in domestic cats worldwide. Although a potential association between FeMV infection and tubulointerstitial nephritis (TIN) has been suggested, this has not been proven, and the subject remains controversial. TIN is the most frequent histopathological finding in the context of feline chronic kidney disease (CKD), which is one of the major clinical pathologies in feline medicine. FeMV research has mainly focused on defining the epidemiology, the role of FeMV in the development of CKD, and its in vitro tropism, but the pathogenicity of FeMV is still not clear, partly due to its distinctive biological characteristics, as well as to a lack of a cell culture system for its rapid isolation. In this review, we summarize the current knowledge of FeMV infection, including genetic diversity of FeMV strains, epidemiology, pathogenicity, and clinicopathological findings observed in naturally infected cats. MDPI 2021-04-15 /pmc/articles/PMC8071394/ /pubmed/33921104 http://dx.doi.org/10.3390/v13040683 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Luca, Eliana Sautto, Giuseppe Andrea Crisi, Paolo Emidio Lorusso, Alessio Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? |
title | Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? |
title_full | Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? |
title_fullStr | Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? |
title_full_unstemmed | Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? |
title_short | Feline Morbillivirus Infection in Domestic Cats: What Have We Learned So Far? |
title_sort | feline morbillivirus infection in domestic cats: what have we learned so far? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071394/ https://www.ncbi.nlm.nih.gov/pubmed/33921104 http://dx.doi.org/10.3390/v13040683 |
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