Knockdown of RRM1 with Adenoviral shRNA Vectors to Inhibit Tumor Cell Viability and Increase Chemotherapeutic Sensitivity to Gemcitabine in Bladder Cancer Cells

RRM1—an important DNA replication/repair enzyme—is the primary molecular gemcitabine (GEM) target. High RRM1-expression associates with gemcitabine-resistance in various cancers and RRM1 inhibition may provide novel cancer treatment approaches. Our study elucidates how RRM1 inhibition affects cancer...

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Detalles Bibliográficos
Autores principales: Zhang, Xia, Taoka, Rikiya, Liu, Dage, Matsuoka, Yuki, Tohi, Yoichiro, Kakehi, Yoshiyuki, Sugimoto, Mikio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071414/
https://www.ncbi.nlm.nih.gov/pubmed/33921102
http://dx.doi.org/10.3390/ijms22084102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071414/
https://www.ncbi.nlm.nih.gov/pubmed/33921102
http://dx.doi.org/10.3390/ijms22084102

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