Convection Enhanced Delivery in the Setting of High-Grade Gliomas

Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery...

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Detalles Bibliográficos
Autores principales: Nwagwu, Chibueze D., Immidisetti, Amanda V., Jiang, Michael Y., Adeagbo, Oluwasegun, Adamson, David C., Carbonell, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071501/
https://www.ncbi.nlm.nih.gov/pubmed/33921157
http://dx.doi.org/10.3390/pharmaceutics13040561
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author Nwagwu, Chibueze D.
Immidisetti, Amanda V.
Jiang, Michael Y.
Adeagbo, Oluwasegun
Adamson, David C.
Carbonell, Anne-Marie
author_facet Nwagwu, Chibueze D.
Immidisetti, Amanda V.
Jiang, Michael Y.
Adeagbo, Oluwasegun
Adamson, David C.
Carbonell, Anne-Marie
author_sort Nwagwu, Chibueze D.
collection PubMed
description Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas.
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spelling pubmed-80715012021-04-26 Convection Enhanced Delivery in the Setting of High-Grade Gliomas Nwagwu, Chibueze D. Immidisetti, Amanda V. Jiang, Michael Y. Adeagbo, Oluwasegun Adamson, David C. Carbonell, Anne-Marie Pharmaceutics Review Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas. MDPI 2021-04-15 /pmc/articles/PMC8071501/ /pubmed/33921157 http://dx.doi.org/10.3390/pharmaceutics13040561 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nwagwu, Chibueze D.
Immidisetti, Amanda V.
Jiang, Michael Y.
Adeagbo, Oluwasegun
Adamson, David C.
Carbonell, Anne-Marie
Convection Enhanced Delivery in the Setting of High-Grade Gliomas
title Convection Enhanced Delivery in the Setting of High-Grade Gliomas
title_full Convection Enhanced Delivery in the Setting of High-Grade Gliomas
title_fullStr Convection Enhanced Delivery in the Setting of High-Grade Gliomas
title_full_unstemmed Convection Enhanced Delivery in the Setting of High-Grade Gliomas
title_short Convection Enhanced Delivery in the Setting of High-Grade Gliomas
title_sort convection enhanced delivery in the setting of high-grade gliomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071501/
https://www.ncbi.nlm.nih.gov/pubmed/33921157
http://dx.doi.org/10.3390/pharmaceutics13040561
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