The Mechanisms of the Development of Atherosclerosis in Prediabetes

Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to ch...

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Detalles Bibliográficos
Autores principales: Liang, Yin, Wang, Mengxue, Wang, Chen, Liu, Yun, Naruse, Keiji, Takahashi, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071517/
https://www.ncbi.nlm.nih.gov/pubmed/33921168
http://dx.doi.org/10.3390/ijms22084108
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author Liang, Yin
Wang, Mengxue
Wang, Chen
Liu, Yun
Naruse, Keiji
Takahashi, Ken
author_facet Liang, Yin
Wang, Mengxue
Wang, Chen
Liu, Yun
Naruse, Keiji
Takahashi, Ken
author_sort Liang, Yin
collection PubMed
description Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.
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spelling pubmed-80715172021-04-26 The Mechanisms of the Development of Atherosclerosis in Prediabetes Liang, Yin Wang, Mengxue Wang, Chen Liu, Yun Naruse, Keiji Takahashi, Ken Int J Mol Sci Review Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis. MDPI 2021-04-15 /pmc/articles/PMC8071517/ /pubmed/33921168 http://dx.doi.org/10.3390/ijms22084108 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liang, Yin
Wang, Mengxue
Wang, Chen
Liu, Yun
Naruse, Keiji
Takahashi, Ken
The Mechanisms of the Development of Atherosclerosis in Prediabetes
title The Mechanisms of the Development of Atherosclerosis in Prediabetes
title_full The Mechanisms of the Development of Atherosclerosis in Prediabetes
title_fullStr The Mechanisms of the Development of Atherosclerosis in Prediabetes
title_full_unstemmed The Mechanisms of the Development of Atherosclerosis in Prediabetes
title_short The Mechanisms of the Development of Atherosclerosis in Prediabetes
title_sort mechanisms of the development of atherosclerosis in prediabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8071517/
https://www.ncbi.nlm.nih.gov/pubmed/33921168
http://dx.doi.org/10.3390/ijms22084108
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